Boye Theresa Louise, Hammerhøj Alexander, Nielsen Ole Haagen, Wang Yulan
Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark.
Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark.
Life Sci. 2024 Dec 15;359:123238. doi: 10.1016/j.lfs.2024.123238. Epub 2024 Nov 12.
Metabolomics is an emerging field involving the systematic identification and quantification of numerous metabolites in biological samples. Precision medicine applies multiomics systems biology to individual patients for reliable diagnostic classification, disease monitoring, and treatment. Multiomics systems biology encompasses genomics, transcriptomics, proteomics, epigenomics, and metabolomics. Therefore, metabolomic techniques could be highly valuable for future clinical decision-making. This review provides a technical overview of two commonly used techniques for metabolomics measurements: mass spectrometry (MS) and proton nuclear magnetic resonance (H NMR) spectroscopy. We also discuss recent clinical advances in these techniques. Individuals with inflammatory bowel disease (IBD) exhibit significant variability in prognosis and response to treatment. Since both genetic predisposition and environmental factors contribute to this condition, targeting the metabolome may provide key insights for distinguishing and profiling patients with different clinical needs. Additionally, the considerable overlap in the clinical presentation of various disease subtypes emphasizes the need for enhanced diagnostic methods to improve patient care.
代谢组学是一个新兴领域，涉及对生物样品中众多代谢物进行系统鉴定和定量。精准医学将多组学系统生物学应用于个体患者，以进行可靠的诊断分类、疾病监测和治疗。多组学系统生物学包括基因组学、转录组学、蛋白质组学、表观基因组学和代谢组学。因此，代谢组学技术对未来的临床决策可能具有很高的价值。本综述提供了两种常用的代谢组学测量技术的技术概述：质谱（MS）和质子核磁共振（H NMR）光谱。我们还讨论了这些技术最近的临床进展。炎症性肠病（IBD）患者的预后和对治疗的反应存在显著差异。由于遗传易感性和环境因素都导致了这种情况，针对代谢组可能为区分和描述具有不同临床需求的患者提供关键见解。此外，各种疾病亚型临床表现的大量重叠强调了需要改进诊断方法以改善患者护理。
