pyroptosis 和纤维化疾病：2010 年至 2024 年的文献计量分析。
The pyroptosis and fibrotic diseases: a bibliometric analysis from 2010 to 2024.
机构信息
Academician Workstation for Oral-Maxillofacial and Regenerative Medicine, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan, 410008, China.
State Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, ChineseAcademy of Medical Sciences, Sichuan University, Chengdu, Sichuan, 610041, China.
出版信息
Syst Rev. 2024 Nov 13;13(1):279. doi: 10.1186/s13643-024-02703-0.
BACKGROUND
Fibrosis is the ultimate, common pathological ending of most chronic inflammatory diseases and increases the chances of developing life-threatening illnesses. Pyroptosis, a newfound form of lytic programmed cell death initiated by the inflammasome, has received more and more attention because of its association with fibrotic diseases. Therefore, this study visualizes the connection between pyroptosis and fibrosis research through bibliometric methods, aimed at providing global research hits and tendencies in the field.
METHODS
We collected and analyzed the articles on pyroptosis and fibrosis from 2010 to 2024 via Web of Science. Visual data analysis was performed for countries, institutions, authors, references, and keywords in the field using VOSviewer, CiteSpace software, the "Bibliometrix" R package, the bibliometric website ( https://bibliometric.com/ ), and Excel software. We analyzed the data by utilizing the bibliometric review method.
RESULTS
A total of 566 articles and reviews relating to pyroptosis and fibrosis were identified in the Web of Science. The number of publications in the domain has continued to grow since 2010. These scientific outputs were mainly from 129 countries/regions and 1919 institutions, particularly China (n = 423) and the USA (n = 83). More importantly, although China publishes a vast majority of articles, its centrality is lower than that of the USA (0.59 vs 0.61). Among the 3833 authors involved in this field, Feldstein, A. E. is the most prolific author. Shi, J. J. is the world's most-cited author among the 12,143 authors in these academic journals. Frontiers in Immunology was a prolific contributor, and Nature was the most frequently cited journal. After analysis, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death were the top-cited articles. The analysis of keywords displayed that pyroptosis, fibrosis, and pathways were the main research hotspots and frontier directions in recent years.
CONCLUSION
We analyzed the characteristics of published articles and drew a fundamental knowledge structure on pyroptosis and fibrosis research via bibliometric analysis. The potential mechanism between fibrosis and pyroptosis is deeply tied to the current moment. Our findings can help researchers make clear the research status and value of fibrosis and pyroptosis and provide new directions for future research as soon as possible.
背景
纤维化是大多数慢性炎症性疾病的最终共同病理结局，增加了罹患危及生命疾病的机会。细胞焦亡是一种新发现的由炎症小体引发的细胞程序性溶解死亡方式，由于与纤维化疾病有关，因此受到越来越多的关注。因此，本研究通过文献计量学方法将细胞焦亡与纤维化研究联系起来，旨在为该领域提供全球研究热点和趋势。
方法
我们通过 Web of Science 收集并分析了 2010 年至 2024 年间关于细胞焦亡和纤维化的文章。使用 VOSviewer、CiteSpace 软件、"Bibliometrix"R 包、文献计量网站（https://bibliometric.com/）和 Excel 软件对该领域的国家、机构、作者、参考文献和关键词进行可视化数据分析。我们通过文献计量学综述方法分析数据。
结果
在 Web of Science 中共确定了 566 篇与细胞焦亡和纤维化相关的文章和综述。自 2010 年以来，该领域的出版物数量持续增长。这些科学产出主要来自 129 个国家/地区和 1919 个机构，特别是中国（n=423）和美国（n=83）。更重要的是，尽管中国发表了绝大多数文章，但它的中心度低于美国（0.59 对 0.61）。在涉及该领域的 3833 位作者中，Feldstein，A.E.是最有影响力的作者。Shi，J.J.是这些学术期刊中最受引用的作者。Frontiers in Immunology 是一个多产的贡献者，而 Nature 是最常被引用的期刊。分析后发现，炎性小体切割 GSDMD 决定细胞焦亡。对关键词的分析表明，细胞焦亡、纤维化和途径是近年来的主要研究热点和前沿方向。
结论
我们通过文献计量分析分析了发表文章的特点，绘制了细胞焦亡和纤维化研究的基本知识结构。纤维化和细胞焦亡之间的潜在机制与当前时刻紧密相关。我们的研究结果可以帮助研究人员了解纤维化和细胞焦亡的研究现状和价值，并尽快为未来的研究提供新的方向。
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