Maniaci Giuseppe, Daino Marco, Iapichino Maria, Giammanco Alessandra, Taormina Calogero, Bonura Giuseppina, Sardella Zaira, Carolla Giuseppe, Cammareri Patrizia, Sberna Emanuele, Clesi Maria Francesca, Ferraro Laura, Gambino Caterina Maria, Ciaccio Marcello, Rispoli Luciano, La Cascia Caterina, La Barbera Daniele, Quattrone Diego
Department of Biomedicine, Neuroscience and Advanced Diagnostic, Section of Psychiatry, (BiND), University of Palermo, Palermo, Italy.
Neo-Functional Psychotherapy Study Centre, Palermo, Italy.
Stress Health. 2024 Dec;40(6):e3503. doi: 10.1002/smi.3503. Epub 2024 Nov 14.
We examined the feasibility of using the neofunctional deep breathing (NDB) technique to reduce the allostatic load following the Trier Social Stress Test (TSST). Forty-four healthy subjects were randomised into experimental and control groups. Following the TSST procedure, participants underwent either a single session of NDB or an attention control intervention. The Procomp Infinity Biofeedback system measured breath per minute (BPM), respiratory amplitude, HRV linear domains, skin conductance, and trapezius muscle electromyographic activity. Cortisol and cytokine salivary concentrations, perceived stress, and anxiety levels were also assessed. These parameters were combined into an allostatic load index (ALI) to measure the intervention's effect. This pilot RCT demonstrated the feasibility of the study design and practicality of the intervention. The NDB group showed reduced ALI, increased respiratory abdominal amplitude, decreased BPM, increased HRV indicating parasympathetic activation, and decreased cortisol and inflammatory cytokines. This study highlighted the feasibility of testing the NDB technique in reducing allostatic load through a neurobiological and anti-inflammatory response after exposure to psychosocial stress. This protocol can represent a non-invasive therapeutic adjutant in disorders related to a dysregulation of the HPA axis or to an inflammatory state. Trial Registration: NCT04102813.
我们研究了采用新功能深呼吸（NDB）技术降低特里尔社会应激测试（TSST）后应激负荷的可行性。44名健康受试者被随机分为实验组和对照组。在TSST程序之后，参与者接受了单次NDB干预或注意力控制干预。Procomp Infinity生物反馈系统测量了每分钟呼吸次数（BPM）、呼吸幅度、心率变异性线性域、皮肤电导率和斜方肌肌电图活动。还评估了唾液皮质醇和细胞因子浓度、感知压力和焦虑水平。这些参数被整合为一个应激负荷指数（ALI），以衡量干预效果。这项初步随机对照试验证明了研究设计的可行性和干预措施的实用性。NDB组的ALI降低，呼吸腹部幅度增加，BPM降低，心率变异性增加表明副交感神经激活，皮质醇和炎性细胞因子减少。本研究强调了通过测试NDB技术，在暴露于心理社会应激后通过神经生物学和抗炎反应来降低应激负荷的可行性。该方案可作为与下丘脑-垂体-肾上腺（HPA）轴失调或炎症状态相关疾病的一种非侵入性治疗辅助手段。试验注册号：NCT04102813。
