Sears M R, Rea H H, Fenwick J, Beaglehole R, Gillies A J, Holst P E, O'Donnell T V, Rothwell R P, Sutherland D C
Arch Dis Child. 1986 Jan;61(1):6-10. doi: 10.1136/adc.61.1.6.
We report the first complete population based study of childhood deaths due to asthma. All deaths ascribed to asthma in New Zealand children aged 0-14 were investigated as part of a two year national study of mortality from asthma. The 16 children who died from asthma all developed asthma by the age of 4; 15 had a family history of asthma, and 12 had associated atopic disorders. Disturbed pyschosocial relationships were evident in eight families. Seven children died in less than three hours from the onset of their final attack. All children died outside hospital. Mortality from asthma in Maori children (3.14 per 100 000) was five times that of European children. With hindsight, factors which if avoided could have led to a different outcome were identified in eleven cases. The circumstances surrounding these deaths were similar to those described for adults with asthma; this study, however, underlines the importance of parental care and knowledge in the management of children with asthma. Inadequate long term medical care, underassessment of severity by family and doctors, failure of the family to call for help when required, and inadequate responses of medical services contributed to the fatalities. Excess beta2 sympathomimetic dosage or overreliance on home nebulisers were uncommon. Most childhood deaths from asthma should be prevented by increased family awareness, better assessment of severity, improved long term treatment, and rapid access to emergency medical care.
我们报告了第一项基于人群的儿童哮喘死亡完整研究。作为一项为期两年的全国哮喘死亡率研究的一部分,对新西兰0至14岁儿童中所有归因于哮喘的死亡病例进行了调查。16名死于哮喘的儿童均在4岁前患上哮喘;15名有哮喘家族史,12名伴有特应性疾病。8个家庭存在明显的心理社会关系困扰。7名儿童在最后一次发作开始后不到三小时内死亡。所有儿童均死于院外。毛利儿童的哮喘死亡率(每10万人中有3.14人)是欧洲儿童的五倍。事后分析发现,11例病例中存在一些若能避免就可能导致不同结果的因素。这些死亡事件的情况与成年哮喘患者的情况类似;然而,这项研究强调了父母护理和知识在儿童哮喘管理中的重要性。长期医疗护理不足、家庭和医生对严重程度评估不足、家庭在需要时未呼救以及医疗服务反应不足导致了这些死亡。β2拟交感神经药剂量过大或过度依赖家用雾化器的情况并不常见。提高家庭意识、更好地评估严重程度、改善长期治疗以及快速获得紧急医疗护理,大多数儿童哮喘死亡是可以预防的。