Lee D A, Winslow N R, Speight A N, Hey E N
Br Med J (Clin Res Ed). 1983 Apr 16;286(6373):1256-8. doi: 10.1136/bmj.286.6373.1256.
All the 7 year old schoolchildren in North Tyneside were screened for wheeze with a questionnaire followed by selective clinical assessment: 9.3% of the children had had episodic wheeze within the past year and all those followed up subsequently responded to one or more of the drugs used for asthma. A further 1.8% had had similar symptoms since starting school, though they had not wheezed in the past year. Frequently of symptoms in the 11% of children with features of asthma varied widely and correlated with bronchial reactivity on histamine challenge, but it was not possible to separate children with frequent wheeze from asymptomatic controls by their response to histamine. It was concluded that all these wheezy children had symptoms of a common basic disorder and that they should all be treated as asthmatic.
对泰恩赛德北部所有7岁学童进行问卷调查以筛查喘息情况，随后进行选择性临床评估：9.3%的儿童在过去一年中曾有发作性喘息，所有后续接受随访的儿童对一种或多种用于哮喘的药物有反应。另有1.8%的儿童自上学以来有类似症状，尽管他们在过去一年中没有喘息。11%有哮喘特征的儿童症状频率差异很大，且与组胺激发试验中的支气管反应性相关，但无法根据对组胺的反应将频繁喘息的儿童与无症状对照儿童区分开来。得出的结论是，所有这些喘息儿童都有共同基本疾病的症状，他们都应被视为哮喘患者进行治疗。
