Stepaniak P C, Furst J J, Woodard D
Aviat Space Environ Med. 1986 Feb;57(2):174-8.
A progressive loss of bone mass is consistently reported in humans exposed to weightlessness during space flight. The mechanism of this metabolic alteration is unknown but may be due in part to the effects of disuse osteoporosis along with the influence of elevated corticosteroid levels. With a goal toward mankind's permanent presence in space, effective countermeasures against bone demineralization will be required. Synthetic anabolic steroids have been shown to prevent bone loss in ground-based immobilization studies and in excess corticosteroid states. These agents may offer a means of slowing or preventing bone loss thus facilitating long term space habitation.
在太空飞行中处于失重状态的人身上，持续报道出现了骨质的逐渐流失。这种代谢改变的机制尚不清楚，但可能部分归因于废用性骨质疏松的影响以及皮质类固醇水平升高的影响。为了人类能在太空中长期生存，需要采取有效的措施来对抗骨质脱矿。在地面固定研究和皮质类固醇过多的状态下，合成代谢类固醇已被证明可预防骨质流失。这些药物可能提供一种减缓或预防骨质流失的方法，从而促进长期的太空居住。
