Qian Huanyu, Wang Lixia, Xu Jie, He Tao, Liu Jian, Duan Zhijun
The Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Comprehensive Internal Medicine, Dalian Lvshunkou District Traditional Chinese Medicine Hospital, Dalian, China.
J Thorac Dis. 2024 Oct 31;16(10):6545-6552. doi: 10.21037/jtd-24-817. Epub 2024 Oct 14.
A discernible correlation exists between gastroesophageal reflux disease (GERD) and chronic obstructive pulmonary disease (COPD). However, the precise nature of the association between reflux esophagitis (RE) and COPD remains inadequately understood. In this study, we investigated the link between RE and pulmonary function, with a specific emphasis on elucidating the interplay between RE and COPD regarding lung function.
The study cohort comprised patients who underwent both pulmonary function tests (PFTs) and endoscopic examinations within a one-year period preceding and following their PFTs at The First Affiliated Hospital of Dalian Medical University from April 2021 to October 2023. Key demographic variables including age, gender, body mass index (BMI), as well as results from PFTs and endoscopy, were systematically documented for each participant. Statistical evaluations were conducted utilizing SPSS Statistics version 29.0, with significance determined at a threshold of P<0.05.
Among patients with COPD, there were notable distinctions between cohorts categorized into RE and non-RE groups concerning several pulmonary function parameters, including forced expiratory volume in 1 second (FEV1), the ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC), maximum mid-expiratory flow (MMEF75/25), and expiratory reserve volume (ERV). Furthermore, there were statistically significant disparities observed in peak expiratory flow (PEF). Overall, RE did not exhibit an association with COPD severity, and there was no notable correlation found between the COPD severity and RE.
RE has been identified as a factor contributing to diminished pulmonary function in both individuals without underlying respiratory conditions and those diagnosed with COPD. Nevertheless, an absence of interaction was observed between the severity of COPD and the presence of RE.
胃食管反流病（GERD）与慢性阻塞性肺疾病（COPD）之间存在明显的相关性。然而，反流性食管炎（RE）与COPD之间关联的确切性质仍未得到充分理解。在本研究中，我们调查了RE与肺功能之间的联系，特别着重于阐明RE与COPD在肺功能方面的相互作用。
研究队列包括在大连医科大学附属第一医院于2021年4月至2023年10月期间进行肺功能测试（PFT）的患者，且在其PFT前后一年内还接受了内镜检查。为每位参与者系统记录了包括年龄、性别、体重指数（BMI）等关键人口统计学变量，以及PFT和内镜检查结果。使用SPSS Statistics 29.0版本进行统计评估，显著性以P<0.05为阈值确定。
在COPD患者中，分为RE组和非RE组的队列在几个肺功能参数方面存在显著差异，包括1秒用力呼气量（FEV1）、1秒用力呼气量与用力肺活量之比（FEV1/FVC）、最大呼气中期流速（MMEF75/25）和呼气储备量（ERV）。此外，在呼气峰值流速（PEF）方面观察到统计学上的显著差异。总体而言，RE与COPD严重程度之间未显示出关联，且未发现COPD严重程度与RE之间存在显著相关性。
已确定RE是导致无基础呼吸系统疾病的个体以及被诊断为COPD的个体肺功能下降的一个因素。然而，未观察到COPD严重程度与RE的存在之间存在相互作用。
