Qaiser Ariba, Ali Dr Sajid, Manzoor Dr Sobia
Atta-ur-Rehman School of Applied Biosciences, National University of Sciences and Technology H-12 Islamabad, Islamabad Capital Territory, Pakistan.
Department of Biotechnology Abdul Wali Khan University Mardan, Pakistan.
Heliyon. 2024 Oct 29;10(21):e39635. doi: 10.1016/j.heliyon.2024.e39635. eCollection 2024 Nov 15.
Viruses cause various human diseases, some of which become pandemic outbreaks lack effective treatments and vaccines. This study gathered data on Carica papaya's antiviral effects against various human viruses, highlighting its potential as a natural treatment. Through , , and clinical study analysis, we illustrated the potential of Carica papaya in combating viral infections and its potential role in cure of common viral diseases.
ology: Research papers on antiviral activity of Carica papaya were identified by using specific keywords in PUBMED, Google Scholar, and ScienceDirect databases. Articles published between January 2015 and March 2024 were screened for inclusion. Eligible studies utilized Carica papaya leaves (powder or juice) or fruits to investigate their effects against human viral infections. Each selected study applied either qualitative or quantitative antiviral assays to assess the efficacy of Carica papaya in combating human viruses.
Fifteen studies went through assessment for antiviral properties of Carica papaya, 7 (46.67 %) of them displayed significant activity against the dengue virus, while 1 study (6.67 %) demonstrated moderate/less effectiveness against dengue serotype-2. Two studies (13.33 %) found no anti-dengue effects. Additionally, Carica papaya exhibited strong antiviral activity against SARS-CoV-2 in 2 studies (13.33 %). One study (6.67 %) showed inhibition of both dengue serotype-2 and chikungunya, and 1 study (6.67 %) each demonstrated inhibitory effects against human immunodeficiency virus and Zika virus infections.
The present study listed human diseases for which Carica papaya revealed significant antiviral effects against Dengue virus, Severe acute respiratory syndrome, Human immunodeficiency virus-I, Chikungunya virus and Zika virus suggesting its potential as a treatment candidate for all these viruses. However, the majority of the research involved screening, with minimal and clinical testing. Further studies and clinical trials should be conducted to explore the potential of Carica papaya in the treatment of human viral infections.
病毒引发各种人类疾病，其中一些成为大流行疫情，缺乏有效的治疗方法和疫苗。本研究收集了番木瓜对各种人类病毒的抗病毒作用的数据，突出了其作为一种天然治疗方法的潜力。通过文献综述、荟萃分析和临床研究分析，我们阐述了番木瓜在对抗病毒感染方面的潜力及其在治疗常见病毒性疾病中的潜在作用。
通过在PUBMED、谷歌学术和科学Direct数据库中使用特定关键词，识别关于番木瓜抗病毒活性的研究论文。筛选2015年1月至2024年3月发表的文章以纳入研究。符合条件的研究使用番木瓜叶（粉末或汁液）或果实来研究它们对人类病毒感染的影响。每项选定的研究应用定性或定量抗病毒试验来评估番木瓜对抗人类病毒的功效。
15项研究对番木瓜的抗病毒特性进行了评估，其中7项（46.67%）对登革热病毒显示出显著活性，而1项研究（6.67%）对登革热2型显示出中度/较低的有效性。两项研究（13.33%）未发现抗登革热作用。此外，在两项研究（13.33%）中，番木瓜对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）表现出强大的抗病毒活性。一项研究（6.67%）显示对登革热2型和基孔肯雅热均有抑制作用，还有一项研究（6.67%）分别对人类免疫缺陷病毒和寨卡病毒感染表现出抑制作用。
本研究列出了番木瓜对其显示出显著抗病毒作用的人类疾病，包括登革热病毒、严重急性呼吸综合征、人类免疫缺陷病毒1型、基孔肯雅热病毒和寨卡病毒，表明其作为所有这些病毒治疗候选药物的潜力。然而大部分研究涉及体外筛选，体内和临床测试极少。应进行进一步的体内研究和临床试验，以探索番木瓜在治疗人类病毒感染方面的潜力。
