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猫用集成避孕和基于 RFID 的阴道内装置的生物相容性评估（）：一项初步研究。

Biocompatibility assessment of an integrated contraceptive and RFID-based intravaginal device in cats (): A preliminary study.

机构信息

Program of Veterinary Medicine, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia.

Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia.

出版信息

Open Vet J. 2024 Sep;14(9):2348-2360. doi: 10.5455/OVJ.2024.v14.i9.23. Epub 2024 Sep 30.

DOI:10.5455/OVJ.2024.v14.i9.23
PMID:39553770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11563625/
Abstract

BACKGROUND

An intravaginal device (IVD) made from polyethylene plastic and copper wire, integrated with a radio frequency identification (RFID) chip, was developed as a biocompatible contraceptive and identity device for cats.

AIM

This study evaluates the local and systemic biocompatibility of IVD in five non-pregnant female cats.

METHODS

The IVD was successfully inserted into the vaginal lumen after estrogen administration. Radiographic imaging confirmed the IVD's position, which lasted up to two days post-insertion.

RESULTS

Systemic response, assessed through hematological examinations on days 0, 1, and 3 post-insertion, showed no significant changes in erythrogram and leukogram parameters. Local response, evaluated through vulvar inspection and vaginal cytology on days 0, 1, 3, and 7, revealed no neutrophil infiltration in 4 out of 5 cats, indicating compatibility with vaginal tissue. Furthermore, epithelial cell profile changes were observed, showing an increase in superficial cells, which is typical during the estrus phase.

CONCLUSION

These findings suggest that the IVD is biocompatible and suitable for use as a contraceptive and identity device in cats. However, further long-term studies are necessary to evaluate the device's prolonged efficacy and potential for contraception failure prevention by mating trials.

摘要

背景

一种由聚乙烯塑料和铜丝制成的阴道内装置（IVD），集成了射频识别（RFID）芯片，被开发为一种生物相容性的猫用避孕和身份识别装置。

目的

本研究评估了 5 只未怀孕雌性猫中 IVD 的局部和全身生物相容性。

方法

在雌激素给药后，成功将 IVD 插入阴道腔。放射影像学确认了 IVD 的位置，在插入后持续长达两天。

结果

通过插入后第 0、1 和 3 天的血液学检查评估全身反应，红细胞和白细胞参数没有明显变化。通过第 0、1、3 和 7 天的外阴检查和阴道细胞学评估局部反应，4 只猫中有 4 只没有中性粒细胞浸润，表明与阴道组织相容。此外，观察到上皮细胞形态变化，表现为表层细胞增加，这在发情期是典型的。

结论

这些发现表明 IVD 具有生物相容性，适合用作猫的避孕和身份识别装置。然而，需要进一步的长期研究来评估该装置通过交配试验预防避孕失败的长期效果和潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/34569154820b/OpenVetJ-14-2348-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/f496eca3b0da/OpenVetJ-14-2348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/d368d1ce71fb/OpenVetJ-14-2348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/c03c87c1377b/OpenVetJ-14-2348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/281d6bf6d94f/OpenVetJ-14-2348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/101f9cc0f6e7/OpenVetJ-14-2348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/8e250282e2ce/OpenVetJ-14-2348-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/34569154820b/OpenVetJ-14-2348-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/f496eca3b0da/OpenVetJ-14-2348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/d368d1ce71fb/OpenVetJ-14-2348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/c03c87c1377b/OpenVetJ-14-2348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/281d6bf6d94f/OpenVetJ-14-2348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/101f9cc0f6e7/OpenVetJ-14-2348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/8e250282e2ce/OpenVetJ-14-2348-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743a/11563625/34569154820b/OpenVetJ-14-2348-g007.jpg

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Poult Sci. 2023 Aug;102(8):102799. doi: 10.1016/j.psj.2023.102799. Epub 2023 May 22.
2
Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene.利用携带猫抗苗勒管激素转基因的病毒载体在雌性家猫中实现长效避孕。
Nat Commun. 2023 Jun 6;14(1):3140. doi: 10.1038/s41467-023-38721-0.
3
PyMouseTracks: Flexible Computer Vision and RFID-Based System for Multiple Mouse Tracking and Behavioral Assessment.
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eNeuro. 2023 May 16;10(5). doi: 10.1523/ENEURO.0127-22.2023. Print 2023 May.
4
Progestin intrauterine devices versus copper intrauterine devices for emergency contraception.孕激素宫内节育器与铜宫内节育器用于紧急避孕的比较。
Cochrane Database Syst Rev. 2023 Feb 27;2(2):CD013744. doi: 10.1002/14651858.CD013744.pub2.
5
Estimating the Population of Unowned Free-Ranging Domestic Cats in Denmark Using a Combination of Questionnaires and GPS Tracking.结合问卷调查和GPS追踪估算丹麦无主散养家猫数量
Animals (Basel). 2022 Apr 4;12(7):920. doi: 10.3390/ani12070920.
6
A triple threat: high population density, high foraging intensity and flexible habitat preferences explain high impact of feral cats on prey.三重威胁：高密度的人口、高强度的觅食和灵活的栖息地偏好解释了野猫对猎物的高影响。
Proc Biol Sci. 2021 Jan 13;288(1942):20201194. doi: 10.1098/rspb.2020.1194. Epub 2021 Jan 6.
7
A Long-Term Lens: Cumulative Impacts of Free-Roaming Cat Management Strategy and Intensity on Preventable Cat Mortalities.长期视角：自由放养猫管理策略及强度对可预防猫死亡的累积影响
Front Vet Sci. 2019 Jul 26;6:238. doi: 10.3389/fvets.2019.00238. eCollection 2019.
8
Neutrophil Extravasation Cascade: What Can We Learn from Two-photon Intravital Imaging?中性粒细胞渗出级联反应：我们能从双光子活体成像中学到什么？
Immune Netw. 2016 Dec;16(6):317-321. doi: 10.4110/in.2016.16.6.317. Epub 2016 Dec 22.
9
Static or dynamic intramedullary nailing of femur and tibia.股骨和胫骨的静态或动态髓内钉固定术。
Med Arch. 2015 Apr;69(2):110-3. doi: 10.5455/medarh.2015.69.110-113. Epub 2015 Apr 6.
10
Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.雌激素信号选择性地诱导造血祖细胞和髓系肿瘤细胞凋亡，而不损害稳态造血。
Cell Stem Cell. 2014 Dec 4;15(6):791-804. doi: 10.1016/j.stem.2014.11.002.