Kapur M M, Mokkapati S, Farooq A, Ahsan R K, Laumas K R
Contraception. 1984 Jan;29(1):45-54. doi: 10.1016/0010-7824(84)90057-x.
An alternative method of male contraception is crucial at this stage of increasing population in the developing world. A non-obstructive, non-hormonal, reversible method of male contraception would find acceptance in oriental communities. Our experience with copper IVD in small animals has been encouraging. We present here an extension of the use of the copper IVD in the rhesus monkey. Treated male rhesus ejaculate showed fifteen-to thirty-five-fold increase in copper levels up to 10 months after insertion of Cu IVD . Semen analysis showed an increase of dead sperm (23.0% - 52.3%; control 4.5% - 14.0%) and decrease in percentage of motile sperm (10-30%; control 70-80%). Fertility studies using treated male rhesus of proven fertility from the breeding colony mated with cycling females of proven fertility showed highly significant reduction of fertility up to 13 months (P less than 0.001). Reduction in fertility of the treated rhesus was also significant up to a period of 23 months (P less than 0.01). A reversal of contraceptive effect and increase in sperm count and motility is observed after 13 months post-treatment. Studies are required to achieve an increase in the effective life span of the IVD .
在发展中世界人口不断增长的现阶段，一种替代的男性避孕方法至关重要。一种非阻塞性、非激素、可逆的男性避孕方法将在东方社区获得认可。我们在小动物身上使用铜宫内节育器（IVD）的经验令人鼓舞。我们在此展示了铜IVD在恒河猴身上的应用扩展。在插入铜IVD后长达10个月的时间里，接受治疗的雄性恒河猴射出的精液中铜含量增加了15至35倍。精液分析显示死精增加（23.0% - 52.3%；对照组为4.5% - 14.0%），活动精子百分比下降（10 - 30%；对照组为70 - 80%）。使用来自繁殖群体中已证实具有生育能力的接受治疗的雄性恒河猴与已证实具有生育能力的处于发情期的雌性恒河猴进行交配的生育力研究表明，在长达13个月的时间里生育力显著降低（P小于0.001）。在长达23个月的时间里，接受治疗的恒河猴的生育力降低也很显著（P小于0.01）。在治疗后13个月后观察到避孕效果逆转以及精子数量和活力增加。需要开展研究以延长IVD的有效使用寿命。
