Michael Cleanthis, Taxali Aman, Angstadt Mike, McCurry Katherine L, Weigard Alexander, Kardan Omid, Molloy M Fiona, Toda-Thorne Katherine, Burchell Lily, Dziubinski Maria, Choi Jason, Vandersluis Melanie, Hyde Luke W, Heitzeg Mary M, Sripada Chandra
Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
bioRxiv. 2024 Oct 29:2024.10.29.620865. doi: 10.1101/2024.10.29.620865.
Sleep is critical for healthy brain development and emotional wellbeing, especially during adolescence when sleep, behavior, and neurobiology are rapidly evolving. Theoretical reviews and empirical research have historically focused on how sleep influences mental health through its impact on brain systems. No studies have leveraged data-driven network neuroscience methods to uncover interpretable, brain-wide signatures of sleep duration in adolescence, their socio-environmental origins, or their consequences for cognition and mental health.
Here, we implement graph theory and component-based predictive modeling to examine how a multimodal index of sleep duration is associated with intrinsic brain architecture in 3,173 youth (11-12 years) from the Adolescent Brain Cognitive Development Study.
We demonstrate that network integration/segregation exhibit a strong, generalizable multivariate association with sleep duration. We next identify a single component of brain architecture centered on a single network as the dominant contributor of this relationship. This component is characterized by increasing disconnection of a system - the somatomotor network - from other systems, with shorter sleep duration. Finally, greater somatomotor disconnection is associated with lower socioeconomic resources, longer screen times, reduced cognitive/academic performance, and elevated externalizing problems.
These findings reveal a novel neural signature of shorter sleep in adolescence that is intertwined with environmental risk, cognition, and psychopathology. By robustly elucidating the key involvement of an understudied brain system in sleep, cognition, and psychopathology, this study can inform theoretical and translational research directions on sleep to promote neurobehavioral development and mental health during the adolescent transition.
睡眠对健康的大脑发育和情绪健康至关重要，尤其是在青少年时期，此时睡眠、行为和神经生物学都在快速发展。理论综述和实证研究历来侧重于睡眠如何通过对大脑系统的影响来影响心理健康。尚无研究利用数据驱动的网络神经科学方法来揭示青少年睡眠时长在全脑范围内可解释的特征、其社会环境根源或对认知和心理健康的影响。
在此，我们运用图论和基于成分的预测模型，来研究来自青少年大脑认知发展研究的3173名青少年（11 - 12岁）的睡眠时长多模态指标与大脑内在结构之间的关联。
我们证明网络整合/分离与睡眠时长呈现出强烈的、可推广的多变量关联。接下来，我们确定以单个网络为中心的大脑结构的一个单一成分是这种关系的主要贡献者。该成分的特征是随着睡眠时长缩短，躯体运动网络与其他系统的连接减少。最后，更大程度的躯体运动网络分离与社会经济资源较低、屏幕使用时间较长、认知/学业表现下降以及外化问题增加有关。
这些发现揭示了青少年睡眠不足的一种新的神经特征，它与环境风险、认知和精神病理学相互交织。通过有力地阐明一个未被充分研究的大脑系统在睡眠、认知和精神病理学中的关键作用，本研究可为睡眠方面的理论和转化研究方向提供信息，以促进青少年过渡期间的神经行为发展和心理健康。
