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通过静电纺丝3D技术制备功能化聚（ε-己内酯）/羟基磷灰石支架以促进骨再生

Development of Functionalized Poly(ε-caprolactone)/Hydroxyapatite Scaffolds via Electrospinning 3D for Enhanced Bone Regeneration.

作者信息

Lima Maria José da Silva, de Melo Etelino Feijó, Alves Kleber G B, de Sá Fabrício Bezerra, Alves Júnior Severino

机构信息

Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife 50670-901, Pernambuco, Brazil.

Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco, Vitória de Santo Antão 55600-000, Pernambuco, Brazil.

出版信息

ACS Omega. 2024 Oct 30;9(45):45035-45046. doi: 10.1021/acsomega.4c05264. eCollection 2024 Nov 12.

DOI:10.1021/acsomega.4c05264
PMID:39554400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11561599/
Abstract

Functionalized scaffolds based on biodegradable polymers are materials used in bone tissue engineering. This study presents the development of functionalized fibrous scaffolds, fabricated from poly(ε-caprolactone) (PCL) and hydroxyapatite (HA). To produce this material, a short-distance electrospinning (ES) system was developed by adapting a 3D printer. The morphology and chemical properties of the scaffolds were evaluated using scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. The results confirmed the porous structure and the presence of hydroxyapatite throughout the entire scaffold area. Mechanical tests indicated good elasticity and tensile strength of the scaffolds, favorable for bone regeneration. In vitro tests showed high levels of cell viability. Furthermore, in vivo experiments using a calvarial defect model in rats demonstrated that the PCL/HA scaffold promoted enhanced bone regeneration. Therefore, the PCL/HA scaffold developed through the adapted electrospinning system shows promise for bone repair.

摘要

基于可生物降解聚合物的功能化支架是骨组织工程中使用的材料。本研究展示了由聚（ε-己内酯）（PCL）和羟基磷灰石（HA）制成的功能化纤维支架的开发。为了生产这种材料，通过改装3D打印机开发了一种短距离静电纺丝（ES）系统。使用扫描电子显微镜、X射线衍射、傅里叶变换红外光谱和热重分析对支架的形态和化学性质进行了评估。结果证实了整个支架区域的多孔结构和羟基磷灰石的存在。力学测试表明支架具有良好的弹性和拉伸强度，有利于骨再生。体外测试显示细胞活力水平很高。此外，在大鼠颅骨缺损模型上进行的体内实验表明，PCL/HA支架促进了增强的骨再生。因此，通过改装的静电纺丝系统开发的PCL/HA支架在骨修复方面显示出前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9840/11561599/38f040e28478/ao4c05264_0014.jpg
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本文引用的文献

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Biology (Basel). 2024 Apr 2;13(4):237. doi: 10.3390/biology13040237.
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The Synergetic Effect of 3D Printing and Electrospinning Techniques in the Fabrication of Bone Scaffolds.3D 打印和静电纺丝技术在骨支架制备中的协同效应。
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Integrating coaxial electrospinning and 3D printing technologies for the development of biphasic porous scaffolds enabling spatiotemporal control in tumor ablation and osteochondral regeneration.
整合同轴电纺丝和3D打印技术以开发双相多孔支架，实现肿瘤消融和骨软骨再生中的时空控制。
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Three-Dimensional Scaffolds for Bone Tissue Engineering.用于骨组织工程的三维支架
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Bone Engineering Scaffolds With Exosomes: A Promising Strategy for Bone Defects Repair.含外泌体的骨工程支架：一种治疗骨缺损修复的有前景的策略。
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Electrospun nanofibrous membrane for biomedical application.用于生物医学应用的电纺纳米纤维膜。
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Shape-Memory Materials via Electrospinning: A Review.通过静电纺丝制备形状记忆材料：综述
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