Tortosa Fernando, Gutiérrez Castillo Gamaliel, Izcovich Ariel, Luz Kleber, Dos Santos Thais, Gonzalez-Escobar Gabriel, Ragusa Martin A, Gresh Lionel, Mendez-Rico Jairo A, Reveiz Ludovic
Organización Panamericana de la Salud Washington D.C. Estados Unidos de América Organización Panamericana de la Salud, Washington D.C., Estados Unidos de América.
Rev Panam Salud Publica. 2024 Nov 15;48:e136. doi: 10.26633/RPSP.2024.136. eCollection 2024.
To assess the frequency of symptoms in patients with Oropouche fever and compare them with those observed in patients with dengue and other arboviral diseases.
A systematic review was conducted following the MOOSE and PRISMA reporting guidelines. The review included studies on acute clinical manifestations in patients with Oropouche fever. Searches were conducted in PubMed, Virtual Health Library, Cochrane Library, and Google Scholar up to September 2024. The symptoms of Oropouche fever were compared to those of dengue and other arboviral diseases. Certainty of evidence was assessed using the GRADE approach.
A total of 23 studies covering 3648 patients with Oropouche fever were included. The most frequent symptoms in patients with Oropouche virus infection were fever (97%) and headache (86%). There was no difference in frequency of fever or headache between patients with Oropouche and dengue. However, odynophagia (28%) and abdominal pain (15%) were more frequent in Oropouche than in dengue, with odds ratios (ORs) of 3.20 and 2.50, respectively. Myalgia (69%) and arthralgia (57%) were less frequent in Oropouche fever than in dengue.
Fever and headache are common in Oropouche virus infection, but do not help discriminate it from dengue. However, odynophagia and abdominal pain are more frequent in patients with Oropouche fever, while myalgia, arthralgia, and rash are more prevalent in dengue. These findings may aid in differential diagnosis in areas of arboviral co-circulation. Further studies on the recurrence and duration of symptoms are needed to improve diagnostic strategies.
评估奥罗普切热患者症状的发生频率，并将其与登革热和其他虫媒病毒疾病患者的症状进行比较。
按照MOOSE和PRISMA报告指南进行系统评价。该评价纳入了关于奥罗普切热患者急性临床表现的研究。截至2024年9月，在PubMed、虚拟健康图书馆、Cochrane图书馆和谷歌学术上进行了检索。将奥罗普切热的症状与登革热和其他虫媒病毒疾病的症状进行比较。使用GRADE方法评估证据的确定性。
共纳入23项研究，涉及3648例奥罗普切热患者。奥罗普切病毒感染患者最常见的症状是发热（97%）和头痛（86%）。奥罗普切热患者和登革热患者在发热或头痛的发生频率上没有差异。然而，吞咽痛（28%）和腹痛（15%）在奥罗普切热患者中比在登革热患者中更常见，优势比分别为3.20和2.50。肌痛（69%）和关节痛（57%）在奥罗普切热中比在登革热中更少见。
发热和头痛在奥罗普切病毒感染中很常见，但无助于将其与登革热区分开来。然而，吞咽痛和腹痛在奥罗普切热患者中更常见，而肌痛、关节痛和皮疹在登革热中更普遍。这些发现可能有助于在虫媒病毒共同流行地区进行鉴别诊断。需要进一步研究症状的复发情况和持续时间，以改进诊断策略。
