巴西亚马逊地区出现新型重组奥罗普切病毒的人间疫情。
Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region.
作者信息
Naveca Felipe Gomes, Almeida Tatiana Amaral Pires de, Souza Victor, Nascimento Valdinete, Silva Dejanane, Nascimento Fernanda, Mejía Matilde, Oliveira Yasmin Silva de, Rocha Luisa, Xavier Natana, Lopes Janis, Maito Rodrigo, Meneses Cátia, Amorim Tatyana, Fé Luciana, Camelo Fernanda Sindeaux, Silva Samyly Coutinho de Aguiar, Melo Alexsandro Xavier de, Fernandes Leíse Gomes, Oliveira Marco Aurélio Almeida de, Arcanjo Ana Ruth, Araújo Guilherme, André Júnior Walter, Carvalho Renata Lia Coragem de, Rodrigues Rosiane, Albuquerque Stella, Mattos Cristiane, Silva Ciciléia, Linhares Aline, Rodrigues Taynã, Mariscal Francy, Morais Márcia Andréa, Presibella Mayra Marinho, Marques Nelson Fernando Quallio, Paiva Anne, Ribeiro Karina, Vieira Deusilene, Queiroz Jackson Alves da Silva, Passos-Silva Ana Maísa, Abdalla Lígia, Santos João Hugo, Figueiredo Regina Maria Pinto de, Cruz Ana Cecília Ribeiro, Casseb Livia Neves, Chiang Jannifer Oliveira, Frutuoso Livia Vinhal, Rossi Agata, Freitas Lucas, Campos Túlio de Lima, Wallau Gabriel Luz, Moreira Emerson, Lins Neto Roberto Dias, Alexander Laura W, Sun Yining, Filippis Ana Maria Bispo de, Gräf Tiago, Arantes Ighor, Bento Ana I, Delatorre Edson, Bello Gonzalo
机构信息
Núcleo de Vigilância de Vírus Emergentes, Reemergentes ou Negligenciados - ViVER/EDTA, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Brazil.
Laboratório de Arbovírus e Vírus Hemorrágicos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
出版信息
Nat Med. 2024 Dec;30(12):3509-3521. doi: 10.1038/s41591-024-03300-3. Epub 2024 Sep 18.
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. In this study, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia and Ecuador (2008-2021). The novel reassortant likely emerged in the Amazonas state between 2010 and 2014 and spread through long-range dispersion events during the second half of the 2010s. Phylodynamics reconstructions showed that the current OROV spread was driven mainly by short-range (< 2 km) movements consistent with the flight range of vectors. Nevertheless, a substantial proportion (22%) of long-range (>10 km) OROV migrations were also detected, consistent with viral dispersion by humans. Our data provide a view of the unprecedented spread and evolution of OROV in the Brazilian western Amazon region.
巴西西部亚马逊地区正在经历有记录以来最大规模的经实验室确认的奥罗普切病毒（OROV）疫情，2022年至2024年间报告的病例超过6300例。在本研究中，我们对2022年8月至2024年2月期间在亚马孙州、阿克里州、朗多尼亚州和罗赖马州采集的人类样本中的382个OROV基因组进行了测序和分析，以揭示当前疫情中OROV的起源和基因演变。基因组分析显示，巴西亚马逊地区OROV病例的激增与一种新型重配谱系的传播相吻合，该谱系包含在亚马逊东部地区（2009 - 2018年）检测到的病毒的M片段以及在秘鲁、哥伦比亚和厄瓜多尔（2008 - 2021年）检测到的病毒的L和S片段。这种新型重配病毒可能于2010年至2014年间在亚马孙州出现，并在2010年代后半期通过远距离传播事件扩散开来。系统动力学重建表明，当前OROV的传播主要是由与媒介飞行范围一致的短距离（<2公里）移动驱动的。然而，也检测到相当比例（22%）的远距离（>10公里）OROV迁移，这与人类导致的病毒扩散一致。我们的数据展现了OROV在巴西西部亚马逊地区前所未有的传播和演变情况。
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