Giri Mohan, Puri Anju, Yadav Shiv Kumar, Chen Yi
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Department of Nursing, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Med Int (Lond). 2025 Aug 27;5(6):67. doi: 10.3892/mi.2025.266. eCollection 2025 Nov-Dec.
Oropouche virus (OROV) is emerging as a growing public health concern, with increasing numbers of case, an expanding global spread and the potential for severe clinical outcomes. However, despite the increasing incidence, the clinical features of OROV infections have not yet been thoroughly examined. The present systematic review and meta-analysis aimed to investigate the prevalence of clinical manifestations in OROV infections. For this purpose, a comprehensive search across PubMed, Web of Science and Embase was conducted up to April 9, 2025, to identify relevant studies. A random effects model was employed to calculate the pooled prevalence and 95% confidence intervals were calucalted. Heterogeneity was assessed using the I statistic. Additionally, sensitivity analyses and publication bias assessments were conducted to ensure the robustness of our findings. The present study included 28 articles and assessed 4,196 patients with OROV infection from 6 countries across the globe. The pooled prevalence of clinical manifestations of OROV included fever (97%), headache (86.5%), myalgia (72.3%), malaise or fatigue (56.4%), arthralgia (50.3%), chills (49.6%), loss of appetite (44.3%), eye pain (43.2%), back pain (31.7%), pallor (31.7%), dizziness (30.2%), photophobia (30.9%), nausea/vomiting (28.9%), sore throat (26.1%), odynophagia (22.9%), diarrhea (18.4%), skin rash (18.2%), conjunctival injection (15.4%), abdominal pain (16.3%), petechiae (2.3%), cough (12.9%), and chest pain (0.7%). High heterogeneity was detected among the included studies, which may be attributed to differences in geographic locations and diagnostic methodologies. Sensitivity analyses further supported the robustness of our findings. On the whole, the present systematic review provides a comprehensive analysis of the clinical manifestations of OROV infection, highlighting key symptoms that may aid in differential diagnosis in arbovirus-endemic regions. The findings may provide critical insight for clinicians and public health professionals and lay the groundwork for future research on the pathogenesis and epidemiology of OROV.
奥罗普切病毒（OROV）正日益成为一个备受关注的公共卫生问题，病例数不断增加，全球传播范围不断扩大，且有可能导致严重的临床后果。然而，尽管发病率不断上升，但OROV感染的临床特征尚未得到全面研究。本系统评价和荟萃分析旨在调查OROV感染中临床表现的患病率。为此，截至2025年4月9日，对PubMed、科学网和Embase进行了全面检索，以识别相关研究。采用随机效应模型计算合并患病率，并计算95%置信区间。使用I统计量评估异质性。此外，还进行了敏感性分析和发表偏倚评估，以确保我们研究结果的稳健性。本研究纳入了28篇文章，评估了来自全球6个国家的4196例OROV感染患者。OROV感染临床表现的合并患病率包括发热（97%）、头痛（86.5%）、肌痛（72.3%）、不适或疲劳（56.4%）、关节痛（50.3%）、寒战（49.6%）、食欲不振（44.3%）、眼痛（43.2%）、背痛（31.7%）、面色苍白（31.7%）、头晕（30.2%）、畏光（30.9%）、恶心/呕吐（28.9%）、咽痛（26.1%）、吞咽痛（22.9%）、腹泻（18.4%）、皮疹（18.2%）、结膜充血（15.4%）、腹痛（16.3%）、瘀点（2.3%）、咳嗽（12.9%）和胸痛（0.7%）。纳入研究中检测到高度异质性，这可能归因于地理位置和诊断方法的差异。敏感性分析进一步支持了我们研究结果的稳健性。总体而言，本系统评价对OROV感染的临床表现进行了全面分析，突出了可能有助于虫媒病毒流行地区进行鉴别诊断的关键症状。这些发现可能为临床医生和公共卫生专业人员提供重要见解，并为未来OROV发病机制和流行病学研究奠定基础。
