Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Occupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Sci Rep. 2024 Nov 18;14(1):28461. doi: 10.1038/s41598-024-79929-4.
Coffee, tea and caffeinated foods are popular in the world due to their high amount of caffeine, which are consumed daily by people in large quantities, and their effects on the body, especially the liver, are somewhat unknown, so this study was done with the aim of relationship between coffee and tea consumption and dietary intake of Caffeine on the serum liver enzymes and lipid profile. In this cross-sectional study the information of 8889 participants aged 35-70 years who referred to the Rafsanjan Cohort Study (RCS), a population-based prospective cohort that is a part of the Prospective epidemiological research studies in Iran (PERSIAN), was used. Demographic characteristics, medical history, consumption of coffee and tea, caffeine intake, and laboratory tests were collected. Dichotomous logistics regression models were used using crude and adjusted models to investigate the relationship between coffee, tea consumption, and caffeine intake with liver enzymes and lipid profile. Out of 8889 participants 4678 (52.6%) were female and 4211 (47.4%) were male. In older people, especially men, the consumption of tea and coffee increased and has a direct relationship with the abnormality of total cholesterol (TC) (OR 1.14; 95% CI 1.01 to 1.29). Also, it was observed that increased abnormal Alkaline phosphatase (ALP) (OR 1.22; 95% CI 1.01 to 1.52) and decreased abnormal serum glutamic-oxaloacetic transaminase (SGOT) (OR 0.65; 95% CI 0.46 to 0.93) were significantly associated with a high intake of caffeine. The other variables related to lipid profile and liver enzymes increased with increasing consumption of coffee, tea and intake of caffeine in participants, but did not show a significant increase. A high intake of caffeine and coffee and tea can have adverse effects on some liver enzymes and blood factors. Therefore, care should be taken when using these materials.
由于咖啡因含量高，咖啡、茶和含咖啡因的食物在世界范围内广受欢迎，人们大量日常饮用，其对身体的影响，尤其是对肝脏的影响尚不完全清楚，因此，本研究旨在探讨咖啡和茶的饮用以及咖啡因的饮食摄入与血清肝酶和血脂谱之间的关系。在这项横断面研究中，我们使用了 8889 名年龄在 35-70 岁的参与者的信息，这些参与者来自 Rafsanjan 队列研究（RCS），这是 Prospective epidemiological research studies in Iran（PERSIAN）的一部分，是基于人群的前瞻性队列研究。收集了人口统计学特征、病史、咖啡和茶的饮用、咖啡因摄入以及实验室检查结果。使用二项逻辑回归模型，采用原始和调整后的模型，调查咖啡、茶的饮用和咖啡因摄入与肝酶和血脂谱的关系。在 8889 名参与者中，4678 名（52.6%）为女性，4211 名（47.4%）为男性。在老年人中，尤其是男性中，茶和咖啡的消费增加，与总胆固醇（TC）异常有直接关系（OR 1.14；95%CI 1.01 至 1.29）。此外，还观察到碱性磷酸酶（ALP）异常增加（OR 1.22；95%CI 1.01 至 1.52）和血清谷氨酸草酰乙酸转氨酶（SGOT）异常减少（OR 0.65；95%CI 0.46 至 0.93）与咖啡因高摄入量显著相关。其他与血脂谱和肝酶相关的变量随着参与者中咖啡、茶和咖啡因摄入量的增加而增加，但没有显著增加。高咖啡因和咖啡、茶的摄入可能对一些肝酶和血液因素产生不良影响。因此，在使用这些物质时应谨慎。
