a Department of Epidemiology and Preventive Medicine , Gifu University Graduate School of Medicine , Gifu , Japan.
b Department of Preventive Medicine , Nagoya University Graduate School of Medicine , Nagoya , Japan.
Nutr Cancer. 2018 Nov-Dec;70(8):1210-1216. doi: 10.1080/01635581.2018.1512638. Epub 2018 Nov 20.
We aimed to investigate whether coffee, green tea, and caffeine intake are associated with liver cancer risk, using data of a prospective cohort study. This study included 30,824 participants (14,240 men and 16,584 women) aged 35 years or older in the Takayama study, which was launched on September 1, 1992. The consumption frequencies of coffee and green tea were assessed using a self-administered questionnaire. Caffeine intake was estimated from the consumption frequencies of caffeine-containing beverages and foods and their caffeine content per serving. The incidence of liver cancer was confirmed using regional population-based cancer registries. During the follow-up period of 16 years, a total of 172 participants developed liver cancer. The adjusted hazard ratios and 95% confidence intervals (CIs) in relation to coffee consumption were 0.65 (95% CI: 0.46-0.93) for less than once per day, 0.63 (95% CI: 0.39-1.02) for once per day, and 0.40 (95% CI: 0.20-0.79) for twice per day or more, compared with nondrinkers. No associations with green tea, black tea and caffeine intake were observed. The present study confirmed that coffee consumption significantly reduces liver cancer risk and raises the possibility that caffeine intake might not account for the association.
我们旨在利用前瞻性队列研究的数据，调查咖啡、绿茶和咖啡因的摄入与肝癌风险之间的关系。这项研究纳入了高山市队列研究中的 30824 名参与者（14240 名男性和 16584 名女性），他们的年龄均在 35 岁及以上，该研究于 1992 年 9 月 1 日启动。咖啡和绿茶的消费频率通过自填式问卷进行评估。咖啡因的摄入量是根据含咖啡因饮料和食物的消费频率以及每份食物的咖啡因含量来估算的。肝癌的发病情况通过区域性基于人群的癌症登记处来确认。在 16 年的随访期间，共有 172 名参与者患上了肝癌。与不喝咖啡相比，每天喝咖啡少于 1 次、每天喝咖啡 1 次、每天喝咖啡 2 次或更多次的参与者，其肝癌发病的调整后危险比（HR）和 95%置信区间（CI）分别为 0.65（95%CI：0.46-0.93）、0.63（95%CI：0.39-1.02）和 0.40（95%CI：0.20-0.79）。未观察到绿茶、红茶和咖啡因摄入与肝癌风险之间存在关联。本研究证实，咖啡的摄入可显著降低肝癌风险，并且提示咖啡因的摄入可能不是导致这种关联的原因。
