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Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.

作者信息

Saad Khaled, Elgalaly Nancy Alaa, Ahmad Ahmad Roshdy, Elhoufey Amira, Jaber Hutaf Abdulhadi, Elgenidy Anas

机构信息

Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Department of Pediatrics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.

出版信息

Pediatr Res. 2024 Nov 18. doi: 10.1038/s41390-024-03747-7.

DOI:10.1038/s41390-024-03747-7
PMID:39558119
Abstract
摘要

相似文献

1
Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.肠道微生物群衍生的氧化三甲胺与SIRT1/HMGB1轴：揭示重型β地中海贫血肾损伤机制
Pediatr Res. 2024 Nov 18. doi: 10.1038/s41390-024-03747-7.
2
The gut microbiota metabolite trimethylamine-N-oxide in children with β-thalassemia: potential implication for iron-induced renal tubular dysfunction.β地中海贫血患儿肠道微生物群代谢产物氧化三甲胺：对铁诱导的肾小管功能障碍的潜在影响
Pediatr Res. 2024 Oct 25. doi: 10.1038/s41390-024-03639-w.
3
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.奎尼酸通过肠道微生物群调节 TMA/TMAO 相关脂质代谢和血管内皮功能，从而抑制动脉粥样硬化。
J Transl Med. 2024 Apr 15;22(1):352. doi: 10.1186/s12967-024-05120-y.
4
The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease.鸟苷酸环化酶 C 激动剂利那洛肽可改善腺嘌呤诱导的慢性肾脏病小鼠模型中的肠道-心脏-肾脏轴。
Nephrol Dial Transplant. 2020 Feb 1;35(2):250-264. doi: 10.1093/ndt/gfz126.
5
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.靶向抑制肠道微生物三甲胺 N-氧化物生成可减少慢性肾脏病小鼠模型的肾间质纤维化和功能障碍。
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1239-1255. doi: 10.1161/ATVBAHA.120.314139. Epub 2020 Mar 26.
6
TMAO is involved in kidney-yang deficiency syndrome diarrhea by mediating the "gut-kidney axis".氧化三甲胺通过介导“肠-肾轴”参与肾阳虚证腹泻的发生。
Heliyon. 2024 Jul 30;10(15):e35461. doi: 10.1016/j.heliyon.2024.e35461. eCollection 2024 Aug 15.
7
Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota.白藜芦醇通过重塑肠道微生物群调节氧化三甲胺（TMAO）合成和胆汁酸代谢，减轻TMAO诱导的动脉粥样硬化。
mBio. 2016 Apr 5;7(2):e02210-15. doi: 10.1128/mBio.02210-15.
8
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1.肠道菌群依赖的代谢产物三甲胺 N-氧化物通过间接 ROS 刺激和涉及 AMPK 和 SIRT1 的信号转导促进动脉粥样硬化相关炎症反应。
Nutrients. 2022 Aug 15;14(16):3338. doi: 10.3390/nu14163338.
9
Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in Regulating TMAO-Mediated Inflammatory Response.针对腹泻肾阳虚证的肠-肾轴：四神丸调节 TMAO 介导的炎症反应的作用。
Med Sci Monit. 2024 Jun 20;30:e944185. doi: 10.12659/MSM.944185.
10
Zuogui-Jiangtang-Yishen decoction prevents diabetic kidney disease: Intervene pyroptosis induced by trimethylamine n-oxide through the mROS-NLRP3 axis.左归降糖益肾汤防治糖尿病肾病：通过 mROS-NLRP3 轴干预氧化三甲胺诱导的细胞焦亡。
Phytomedicine. 2023 Jun;114:154775. doi: 10.1016/j.phymed.2023.154775. Epub 2023 Mar 18.

本文引用的文献

1
Differential gut microbiota composition in β-Thalassemia patients and its correlation with iron overload.β-地中海贫血患者肠道菌群组成的差异及其与铁过载的相关性。
Sci Rep. 2024 Oct 11;14(1):23858. doi: 10.1038/s41598-024-75456-4.
2
Could the Crosstalk Between Myeloid-Derived-Suppressor Cells and Regulatory T Cells Have a Role in Beta-Thalassemia?髓源性抑制细胞与调节性T细胞之间的相互作用在β地中海贫血中起作用吗？
J Hematol. 2023 Aug;12(4):161-169. doi: 10.14740/jh1149. Epub 2023 Aug 8.
3
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases.
SIRT1 在内分泌和代谢疾病中的新作用。
Int J Biol Sci. 2023 Jan 1;19(2):484-501. doi: 10.7150/ijbs.78654. eCollection 2023.
4
The SIRT1-HMGB1 axis: Therapeutic potential to ameliorate inflammatory responses and tumor occurrence.SIRT1-HMGB1轴：改善炎症反应和肿瘤发生的治疗潜力。
Front Cell Dev Biol. 2022 Aug 19;10:986511. doi: 10.3389/fcell.2022.986511. eCollection 2022.
5
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1.肠道菌群依赖的代谢产物三甲胺 N-氧化物通过间接 ROS 刺激和涉及 AMPK 和 SIRT1 的信号转导促进动脉粥样硬化相关炎症反应。
Nutrients. 2022 Aug 15;14(16):3338. doi: 10.3390/nu14163338.
6
High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction.高迁移率族蛋白 B1 介导 TMAO 诱导的内皮功能障碍。
Int J Mol Sci. 2019 Jul 22;20(14):3570. doi: 10.3390/ijms20143570.
7
Trimethylamine N-Oxide: The Good, the Bad and the Unknown.氧化三甲胺：有益、有害与未知之处
Toxins (Basel). 2016 Nov 8;8(11):326. doi: 10.3390/toxins8110326.
8
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.胆碱向三甲胺的微生物转化需要甘氨酰基自由基酶。
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21307-12. doi: 10.1073/pnas.1215689109. Epub 2012 Nov 14.