双相障碍的 40Hz 听觉稳态反应：一项荟萃分析。

The 40-Hz auditory steady-state response in bipolar disorder: A meta-analysis.

机构信息

Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

出版信息

Clin Neurophysiol. 2022 Sep;141:53-61. doi: 10.1016/j.clinph.2022.06.014. Epub 2022 Jul 6.

DOI:10.1016/j.clinph.2022.06.014

PMID:35853310

Abstract

OBJECTIVE

Bipolar disorder is characterized by aberrant neurophysiological responses as measured with electroencephalography (EEG) and magnetoencephalography (MEG), including the 40-Hz auditory steady-state response (ASSR). 40-Hz ASSR deficits are also found in patients with schizophrenia and may represent a transdiagnostic biomarker of neuronal circuit dysfunction. In this systematic review and meta-analysis, we summarize and evaluate the evidence for 40-Hz ASSR deficits in patients with bipolar disorder.

METHODS

We identified studies from PubMed, EMBASE, and SCOPUS. We assessed the risk of bias, calculated Hedges' g meta-level effect sizes, and investigated small-study effects using funnel plots and Egger regression.

RESULTS

Seven studies, comprising 396 patients with bipolar disorder and 404 healthy controls, were included in the meta-analysis. Studies displayed methodological heterogeneity and an overall high risk of bias. Patients with bipolar disorder showed consistent reductions in 40-Hz ASSR evoked power (Hedges' g = -0.49; 95% confidence intervals [-0.67, -0.31]) and inter-trial phase coherence (ITPC) (Hedges' g = -0.43; 95 %CI [-0.58, -0.29]) compared with healthy controls.

CONCLUSIONS

Our meta-analysis provides evidence that 40-Hz ASSRs are reduced in patients with bipolar disorder compared with healthy controls.

SIGNIFICANCE

Future large-scale studies are warranted to link 40-Hz ASSR deficits to clinical features and developmental trajectories.

摘要

目的

双相情感障碍的特征是脑电图（EEG）和脑磁图（MEG）测量的异常神经生理反应，包括 40-Hz 听觉稳态反应（ASSR）。在精神分裂症患者中也发现了 40-Hz ASSR 缺陷，这可能代表神经元回路功能障碍的跨诊断生物标志物。在这项系统评价和荟萃分析中，我们总结并评估了双相情感障碍患者 40-Hz ASSR 缺陷的证据。

方法

我们从 PubMed、EMBASE 和 SCOPUS 中确定了研究。我们评估了偏倚风险，计算了 Hedges'g 元水平效应大小，并使用漏斗图和 Egger 回归调查了小样本研究效应。

结果

共有 7 项研究，包括 396 名双相情感障碍患者和 404 名健康对照者，纳入荟萃分析。研究显示方法学异质性和整体高偏倚风险。与健康对照组相比，双相情感障碍患者的 40-Hz ASSR 诱发功率（Hedges'g=-0.49；95%置信区间[-0.67，-0.31]）和试验间相位相干性（ITPC）（Hedges'g=-0.43；95%CI[-0.58，-0.29]）持续降低。