Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Clin Neurophysiol. 2022 Sep;141:53-61. doi: 10.1016/j.clinph.2022.06.014. Epub 2022 Jul 6.
Bipolar disorder is characterized by aberrant neurophysiological responses as measured with electroencephalography (EEG) and magnetoencephalography (MEG), including the 40-Hz auditory steady-state response (ASSR). 40-Hz ASSR deficits are also found in patients with schizophrenia and may represent a transdiagnostic biomarker of neuronal circuit dysfunction. In this systematic review and meta-analysis, we summarize and evaluate the evidence for 40-Hz ASSR deficits in patients with bipolar disorder.
We identified studies from PubMed, EMBASE, and SCOPUS. We assessed the risk of bias, calculated Hedges' g meta-level effect sizes, and investigated small-study effects using funnel plots and Egger regression.
Seven studies, comprising 396 patients with bipolar disorder and 404 healthy controls, were included in the meta-analysis. Studies displayed methodological heterogeneity and an overall high risk of bias. Patients with bipolar disorder showed consistent reductions in 40-Hz ASSR evoked power (Hedges' g = -0.49; 95% confidence intervals [-0.67, -0.31]) and inter-trial phase coherence (ITPC) (Hedges' g = -0.43; 95 %CI [-0.58, -0.29]) compared with healthy controls.
Our meta-analysis provides evidence that 40-Hz ASSRs are reduced in patients with bipolar disorder compared with healthy controls.
Future large-scale studies are warranted to link 40-Hz ASSR deficits to clinical features and developmental trajectories.
双相情感障碍的特征是脑电图（EEG）和脑磁图（MEG）测量的异常神经生理反应，包括 40-Hz 听觉稳态反应（ASSR）。在精神分裂症患者中也发现了 40-Hz ASSR 缺陷，这可能代表神经元回路功能障碍的跨诊断生物标志物。在这项系统评价和荟萃分析中，我们总结并评估了双相情感障碍患者 40-Hz ASSR 缺陷的证据。
我们从 PubMed、EMBASE 和 SCOPUS 中确定了研究。我们评估了偏倚风险，计算了 Hedges'g 元水平效应大小，并使用漏斗图和 Egger 回归调查了小样本研究效应。
共有 7 项研究，包括 396 名双相情感障碍患者和 404 名健康对照者，纳入荟萃分析。研究显示方法学异质性和整体高偏倚风险。与健康对照组相比，双相情感障碍患者的 40-Hz ASSR 诱发功率（Hedges'g=-0.49；95%置信区间[-0.67，-0.31]）和试验间相位相干性（ITPC）（Hedges'g=-0.43；95%CI[-0.58，-0.29]）持续降低。
我们的荟萃分析提供了证据，表明与健康对照组相比，双相情感障碍患者的 40-Hz ASSR 减少。
需要进一步开展大规模研究，将 40-Hz ASSR 缺陷与临床特征和发育轨迹联系起来。
