Puccetti Nikki A, Stamatis Caitlin A, Timpano Kiara R, Heller Aaron S
Department of Psychiatry, The Ohio State University Wexner Medical Center, 1670 Upham Dr, Columbus, OH, 43210, USA.
Department of Psychology, University of Miami, PO Box 248185, Coral Gables, FL, 33124, USA.
Cogn Affect Behav Neurosci. 2025 Apr;25(2):488-500. doi: 10.3758/s13415-024-01239-z. Epub 2024 Nov 19.
Repetitive negative thinking (RNT) captures shared cognitive and emotional features of content-specific cognition, including future-focused worry and past-focused rumination. The degree to which these distinct but related processes recruit overlapping neural structures is undetermined, because most neuroscientific studies only examine worry or rumination in isolation. To address this, we developed a paradigm to elicit idiographic worries and ruminations during an fMRI scan in 39 young adults with a range of trait RNT scores. We measured concurrent emotion ratings and heart rate as a physiological metric of arousal. Multivariate representational similarity analysis revealed that regions distributed across default mode, salience, and frontoparietal control networks encode worry and rumination similarly. Moreover, heart rate did not differ between worry and rumination. Capturing the shared neural features between worry and rumination throughout networks supporting self-referential processing, memory, salience detection, and cognitive control provides novel empirical evidence to bolster cognitive and clinical models of RNT.
重复性消极思维（RNT）涵盖了特定内容认知的共同认知和情感特征，包括对未来的担忧和对过去的沉思。这些不同但相关的过程在多大程度上调用重叠的神经结构尚不确定，因为大多数神经科学研究仅单独考察担忧或沉思。为了解决这个问题，我们开发了一种范式，在功能磁共振成像（fMRI）扫描期间，对39名具有一系列特质RNT分数的年轻人诱发个性化的担忧和沉思。我们测量了同步的情绪评分和心率，作为唤醒的生理指标。多变量表征相似性分析表明，分布在默认模式、突显和额顶叶控制网络中的区域对担忧和沉思的编码相似。此外，担忧和沉思之间的心率没有差异。在支持自我参照加工、记忆、突显检测和认知控制的整个网络中捕捉担忧和沉思之间的共同神经特征，为支持RNT的认知和临床模型提供了新的实证证据。
