植物复方提取物对变形链球菌黏附牙釉质的影响。
The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel.
机构信息
Department of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of Pretoria, Pretoria, 0002, South Africa.
South African International Maritime Institute (SAIMI), Nelson Mandela University, Gqeberha, 6019, South Africa.
出版信息
BMC Complement Med Ther. 2024 Nov 19;24(1):402. doi: 10.1186/s12906-024-04707-8.
BACKGROUND
Dental caries, also known as tooth decay or cavity formation, is one of the world's most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalensis, for example, has been used to treat toothache and gum infections.
METHODS
In this study, the antimicrobial and anti-adherence properties of H. natalensis and Camellia sinensis, as well as tea tree and peppermint essential oils were investigated on tooth enamel.
RESULTS
The bacterial load of S. mutans was reduced by approximately two orders of a magnitude after 48 h, with a lesser extent on the commensal bacteria, Lactobacillus paracasei. Scanning electron micrographs of enamel blocks showed a reduction in the attachment and chain formation of S. mutans and degraded cell morphology. Lastly, the combination and each component individually, showed low to no cellular toxicity when tested on human macrophages.
CONCLUSIONS
This is the first report of this polyherbal regarding its selectivity and potential prevention of dental caries.
背景
龋齿，也被称为蛀牙或龋齿形成，是世界上最普遍的牙齿疾病之一。它是一种由变形链球菌引起的主要与菌斑相关的感染。人们一直依赖几种植物物种来治疗口腔感染；例如，霍特氏副球菌已被用于治疗牙痛和牙龈感染。
方法
在这项研究中，研究了霍特氏副球菌和山茶、茶树和薄荷精油对牙釉质的抗菌和抗黏附特性。
结果
在 48 小时后，变形链球菌的细菌负荷减少了约两个数量级，而共生菌副干酪乳杆菌的减少程度较小。牙釉质块的扫描电子显微镜照片显示，变形链球菌的附着和链形成减少，细胞形态退化。最后，当在人巨噬细胞上测试时，组合和每个单独的成分都显示出低至无细胞毒性。
结论
这是首次报道这种多草药对龋齿的选择性和潜在预防作用。
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