Wang Shu, Jiang Yin, Yang Anchao, Meng Fangang, Zhang Jianguo
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China.
Aging Dis. 2024 Nov 9. doi: 10.14336/AD.2024.1071.
Neurodegenerative diseases, particularly Alzheimer's disease and other dementias as well as Parkinson's disease, are emerging as profoundly significant challenges and burdens to global health, a trend highlighted by the most recent Global Burden of Disease (GBD) 2021 studies. This growing impact is closely linked to the demographic shift toward an aging population and the potential long-term repercussions of the COVID-19 pandemic, both of which have intensified the prevalence and severity of these conditions. In this review, we explore several critical aspects of this complex issue, including the increasing global burden of neurodegenerative diseases, unmet medical and social needs within current care systems, the unique and amplified challenges posed by the COVID-19 pandemic, and potential strategies for enhancing healthcare policy and practice. We underscore the urgent need for cohesive, multidisciplinary approaches across medical, research, and policy domains to effectively address the increasing burden of neurodegenerative diseases, thereby improving the quality of life for patients and their caregivers.
神经退行性疾病，尤其是阿尔茨海默病和其他痴呆症以及帕金森病，正成为全球健康面临的极其重大的挑战和负担，这一趋势在最新的《2021年全球疾病负担》（GBD）研究中得到了凸显。这种日益增长的影响与人口结构向老龄化的转变以及新冠疫情的潜在长期影响密切相关，这两者都加剧了这些疾病的患病率和严重程度。在本综述中，我们探讨了这个复杂问题的几个关键方面，包括神经退行性疾病日益增加的全球负担、当前护理系统中未得到满足的医疗和社会需求、新冠疫情带来的独特且加剧的挑战，以及加强医疗保健政策和实践的潜在策略。我们强调迫切需要在医学、研究和政策领域采取凝聚性的多学科方法，以有效应对神经退行性疾病日益增加的负担，从而改善患者及其护理人员的生活质量。
