AlphaFold 为去孤儿化分泌蛋白打开了大门。

AlphaFold opens the doors to deorphanizing secreted proteins.

机构信息

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India.

出版信息

Cell Syst. 2024 Nov 20;15(11):1000-1001. doi: 10.1016/j.cels.2024.10.010.

DOI:10.1016/j.cels.2024.10.010

Abstract

Danneskiold-Samsøe and coworkers have developed an in silico screening pipeline based on AlphaFold2 for identifying single-pass transmembrane receptors for secreted peptides that play important roles in cell-cell signaling. Their approach can be used to deorphanize a diverse range of ligands. The overall strategy can be valuable in screening for weak and transient interactions.

摘要

丹内斯基尔德-萨姆索和同事们开发了一种基于 AlphaFold2 的计算机筛选管道，用于识别在细胞间信号转导中起重要作用的分泌肽的单次跨膜受体。他们的方法可用于鉴定各种配体。这种整体策略在筛选弱和瞬时相互作用时非常有价值。