Wahren B, Hinkula J, Stigbrand T, Jeppsson A, Andersson L, Esposti P L, Edsmyr F, Millán J L
Int J Cancer. 1986 Apr 15;37(4):595-600. doi: 10.1002/ijc.2910370419.
PLAP-like enzymes could be detected in serum of patients with primary testicular tumors, in particular seminomas. The use of a panel of monoclonal antibodies (MAbs) permitted typing into 6 different testicular serum phenotypes, of which one appeared similar to a placental type (II) and 2 have not been previously described. Most tumor sera belonged to type I, as described for seminoma tissues. With a more advanced tumor the mean serum PLAP-like levels increased. After operation, after radiotherapy or with no evidence of disease lower or non-detectable enzyme levels were found. In typing the tissue PLAP-like antigen in serum of the same patient or sera from recurrences of a seminoma in the same patient, the same phenotypes of PLAP-like antigen were usually but not always found. None of the 6 phenotypes appeared to confer a poorer prognosis. We conclude that the expression of PLAP-like antigen is eutopic and is enhanced by testicular malignancy, especially in seminoma cells.
在原发性睾丸肿瘤（尤其是精原细胞瘤）患者的血清中可检测到胎盘碱性磷酸酶（PLAP）样酶。使用一组单克隆抗体（MAb）可将其分为6种不同的睾丸血清表型，其中一种类似于胎盘型（II型），另外2种以前未曾描述过。如精原细胞瘤组织所述，大多数肿瘤血清属于I型。随着肿瘤进展，血清PLAP样水平均值升高。手术后、放疗后或无疾病证据时，酶水平降低或检测不到。在对同一患者血清中的组织PLAP样抗原进行分型或对同一患者精原细胞瘤复发的血清进行分型时，通常但并非总是能发现相同的PLAP样抗原表型。这6种表型均未显示预后较差。我们得出结论，PLAP样抗原的表达是原位的，并且会因睾丸恶性肿瘤（尤其是在精原细胞瘤细胞中）而增强。
