Sirotiak Zoe, Adamowicz Jenna L, Thomas Emily B K
Department of Kinesiology, Iowa State University, Ames, IA, USA.
Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Qual Life Res. 2025 Mar;34(3):777-787. doi: 10.1007/s11136-024-03854-2. Epub 2024 Nov 23.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is associated with anxiety and depressive symptoms. Psychological symptoms are predisposing factors for, as well as symptoms of, ME/CFS. Recovery from ME/CFS is poorly understood and heterogenous, and it is unclear how psychological symptoms may change with recovery. The aim of this study was to examine the associations of depressive and anxious symptoms among individuals with current, previous, and no history of ME/CFS.
National Health Interview Survey 2022 data were analyzed to assess ME/CFS status, as well as anxiety and depression burden. Adults (unweighted N = 27,651) in the United States reported sociodemographic and health behavior characteristics, with 453 adults reporting current ME/CFS, while 119 reported previous ME/CFS. Sample weights and variance estimation variables were implemented. Multivariable linear regression models were used to analyze the associations between ME/CFS status and anxiety and depression severity after adjusting for sociodemographic and health behavior variables.
Participants were on average 48.1 years of age, and most identified as female (51.3%), white (76.6%), and not Hispanic or Latine (82.8%). Current and previous ME/CFS were associated with anxiety and depressive symptoms compared to individuals with no history of ME/CFS. Clinically significant levels of anxiety and depressive symptoms were substantial for individuals with current (37.6%; 49.0%) and previous (26.5%; 33.4%) ME/CFS compared to individuals with no history of ME/CFS (6.1%; 6.7%).
ME/CFS, regardless of current presence, was related to significantly greater anxiety and depressive symptom burden.
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）与焦虑和抑郁症状相关。心理症状既是ME/CFS的诱发因素，也是其症状。ME/CFS的康复情况尚不清楚且存在异质性，心理症状如何随康复而变化也不明确。本研究的目的是检验有ME/CFS现病史、既往史和无病史个体的抑郁和焦虑症状之间的关联。
分析2022年美国国家健康访谈调查数据，以评估ME/CFS状况以及焦虑和抑郁负担。美国的成年人（未加权N = 27,651）报告了社会人口统计学和健康行为特征，其中453名成年人报告有ME/CFS现病史，119名报告有ME/CFS既往史。采用样本权重和方差估计变量。多变量线性回归模型用于分析在调整社会人口统计学和健康行为变量后，ME/CFS状况与焦虑和抑郁严重程度之间的关联。
参与者平均年龄为48.1岁，大多数人认定为女性（51.3%）、白人（76.6%）且非西班牙裔或拉丁裔（82.8%）。与无ME/CFS病史的个体相比，ME/CFS现病史和既往史与焦虑和抑郁症状相关。与无ME/CFS病史的个体（6.1%；6.7%）相比，有ME/CFS现病史（37.6%；49.0%）和既往史（26.5%；33.4%）的个体存在具有临床意义的焦虑和抑郁症状的比例相当高。
无论ME/CFS是否为现患，均与明显更重的焦虑和抑郁症状负担相关。
