Therapeutic potential of the probiotic BX 62 and its postbiotics in alleviating rheumatoid arthritis in mice.

This study comprehensively investigated the probiotic potential of and its derived postbiotics in alleviating rheumatoid arthritis (RA) symptoms in mice. analyses established the probiotic characteristics of , highlighting its acid tolerance, bile salt resistance, and adhesion abilities. Subsequent experiments demonstrated that administering live significantly reduced arthritis scores, paw oedema, and intestinal permeability in RA mice, indicating its therapeutic potential. Furthermore, the study explored the effects of -derived postbiotics, including both the cellular remnants and supernatant, on RA. Notably, both the inactivated body of and its supernatant effectively reduced osteoarthritic damage, intestinal pathological changes, autoantibody levels, cytokine imbalances, and oxidative stress in RA mice. Additionally, qPCR analysis revealed that interventions restored gut microbiota composition towards a healthier profile, resembling that of normal mice. Collectively, these findings underscore the therapeutic benefits of and its postbiotics in ameliorating RA symptoms, emphasising their potential as novel therapeutic agents for managing RA.