Qin Qi, Hu Gang, Zhou Xiaoni, Zhu Ruizhe, Chen Jianying, Zeng Kangtai, Wu Jingwu, Wei Jing, Chen Tingtao, Guo Xusheng
School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Probiotics and Life Health Institute, Lanzhou University, Lanzhou, 730000, China.
Curr Res Food Sci. 2024 Nov 5;9:100915. doi: 10.1016/j.crfs.2024.100915. eCollection 2024.
This study comprehensively investigated the probiotic potential of and its derived postbiotics in alleviating rheumatoid arthritis (RA) symptoms in mice. analyses established the probiotic characteristics of , highlighting its acid tolerance, bile salt resistance, and adhesion abilities. Subsequent experiments demonstrated that administering live significantly reduced arthritis scores, paw oedema, and intestinal permeability in RA mice, indicating its therapeutic potential. Furthermore, the study explored the effects of -derived postbiotics, including both the cellular remnants and supernatant, on RA. Notably, both the inactivated body of and its supernatant effectively reduced osteoarthritic damage, intestinal pathological changes, autoantibody levels, cytokine imbalances, and oxidative stress in RA mice. Additionally, qPCR analysis revealed that interventions restored gut microbiota composition towards a healthier profile, resembling that of normal mice. Collectively, these findings underscore the therapeutic benefits of and its postbiotics in ameliorating RA symptoms, emphasising their potential as novel therapeutic agents for managing RA.
本研究全面调查了[具体益生菌名称]及其衍生的后生元在减轻小鼠类风湿性关节炎（RA）症状方面的益生菌潜力。[相关]分析确定了[具体益生菌名称]的益生菌特性，突出了其耐酸性、耐胆盐性和黏附能力。随后的[相关]实验表明，给RA小鼠施用活的[具体益生菌名称]可显著降低关节炎评分、爪部水肿和肠道通透性，表明其具有治疗潜力。此外，该研究还探讨了[具体益生菌名称]衍生的后生元（包括细胞残余物和上清液）对RA的影响。值得注意的是，[具体益生菌名称]的灭活菌体及其上清液均有效减轻了RA小鼠的骨关节炎损伤、肠道病理变化、自身抗体水平、细胞因子失衡和氧化应激。此外，qPCR分析显示，[具体益生菌名称]干预使肠道微生物群组成恢复到更健康的状态，类似于正常小鼠。总的来说，这些发现强调了[具体益生菌名称]及其后生元在改善RA症状方面的治疗益处，突出了它们作为治疗RA的新型治疗剂的潜力。
