Weinstein Andrea M, Gogniat Marissa A, Butters Meryl A
School of Medicine, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
J Alzheimers Dis. 2025 Jan;103(2):353-355. doi: 10.1177/13872877241301804. Epub 2024 Nov 25.
This commentary focuses on the clinical utility of plasma amyloid-β (Aβ) 42/40 to detect semantic intrusion errors in amnestic mild cognitive impairment, as investigated Curiel Cid et al. in a recent issue of the . This commentary highlights the importance of testing the sensitivity of plasma Aβ to clinical symptoms in the quest to develop a comprehensive definition of AD that incorporates both biological precursors and clinical consequences.
正如Curiel Cid等人在最近一期的《》中所研究的那样，本评论聚焦于血浆淀粉样蛋白-β（Aβ）42/40在检测遗忘型轻度认知障碍中的语义侵入错误方面的临床效用。本评论强调了在寻求制定一个包含生物学前驱因素和临床后果的全面的阿尔茨海默病定义的过程中，测试血浆Aβ对临床症状敏感性的重要性。
