Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Department of Population Sciences, University of Utah, USA.
Cancer Med. 2024 Nov;13(22):e70431. doi: 10.1002/cam4.70431.
Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established.
We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I-III CRC in the ColoCare Study.
High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03).
Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.
恶病质约占所有癌症相关死亡人数的 20%，并预示着预后不良。结直肠癌（CRC）的微生物危险因素具核梭杆菌（Fn）对恶病质发展的影响尚未确定。
我们评估了 ColoCare 研究中 n = 87 例 I-III 期 CRC 患者术前粪便样本中 Fn 丰度与术后 6 个月恶病质发病之间的关联。
与粪便 Fn 阴性/低丰度相比，粪便 Fn 高丰度与术后 6 个月恶病质发病的风险增加 4 倍相关（OR = 4.82，95%CI = 1.15，20.10，p = 0.03）。
我们的研究结果表明，CRC 患者粪便 Fn 丰度高与术后 6 个月恶病质发病风险增加相关。这是首次将 Fn 丰度与 CRC 患者恶病质联系起来的研究，为癌症恶病质的生物学机制和潜在管理提供了新的见解。由于样本量较小，我们的结果应谨慎解释。需要更大样本量的未来研究来验证这些发现。
