Kochanowicz Magdalena, Brzezinska Paulina, Mieszkowski Jan, Kochanowicz Andrzej, Niespodzinski Bartlomiej, Surmiak Marcin, Reczkowicz Joanna, Borkowska Andzelika, Antosiewicz Jedrzej
Department of Physiotherapy, Medical University of Gdansk, Gdańsk, Poland.
Department of Gymnastics and Dance, Gdansk University of Physical Education and Sport, Gdańsk, Poland.
Front Physiol. 2024 Nov 11;15:1428404. doi: 10.3389/fphys.2024.1428404. eCollection 2024.
Remote ischemic preconditioning (RIPC) is a method of protection against induced ischemia reperfusion injury, and an increasing number of studies showed some of its inconclusive ergogenic effects in sports. RIPC involves short cycles of cuff inflation followed by its deflation which may affect many body systems. While most of the studies focus on single RIPC effects, there is insufficient data regarding training-like repeated RIPC interventions. Thus, in this study, we analyzed the effect of a single- and consecutive 10-day RIPC procedure on a single leg, focusing on the exerkine levels and changes in inflammation markers following the Wingate Anaerobic Test (WAnT).
Two single-blinded, sham-controlled protocols were designed to evaluate the 1) single (crossover study) and 2) consecutive 10-day (parallel study) RIPC effects on the WAnT performance and exercise-induced lactate, glucose, exerkine, and inflammation markers (BDNF; IL-6; IL-10; IL-15; LIF; oncostatin M). In each protocol, 37 physically active men (19.98 ± 1.17 years) were randomly assigned into two groups according to a particular study design.
An increase in participants' mean (4.81%, p < 0.05) and peak power (6.25%, p < 0.05) during the WAnT was observed only after the consecutive 10-day RIPC. Similarly, a significant 15.5% (p < 0.05) decrease in the IL-6 concentration 120 min after the WAnT was observed only in the consecutive 10-day RIPC protocol, as well as a 12.2% (p < 0.01) increase in oncostatin M 60 min after the WAnT.
The results demonstrate the efficacy of the consecutive 10-day RIPC procedure in modulating exercise performance and post-exercise inflammation markers.
远程缺血预处理（RIPC）是一种预防诱导性缺血再灌注损伤的方法，越来越多的研究表明其在运动中的某些促运动效果尚无定论。RIPC包括短暂的袖带充气循环，随后放气，这可能会影响许多身体系统。虽然大多数研究集中在单次RIPC的效果上，但关于类似训练的重复RIPC干预的数据不足。因此，在本研究中，我们分析了单腿单次和连续10天RIPC程序的效果，重点关注温盖特无氧试验（WAnT）后的运动因子水平和炎症标志物变化。
设计了两个单盲、假对照方案，以评估1）单次（交叉研究）和2）连续10天（平行研究）RIPC对WAnT表现以及运动诱导的乳酸、葡萄糖、运动因子和炎症标志物（脑源性神经营养因子；白细胞介素-6；白细胞介素-10；白细胞介素-15；白血病抑制因子；制瘤素M）的影响。在每个方案中，37名身体活跃的男性（19.98±1.17岁）根据特定的研究设计随机分为两组。
仅在连续10天的RIPC后，观察到WAnT期间参与者的平均功率（4.81%，p<0.05）和峰值功率（6.25%，p<0.05）增加。同样，仅在连续10天的RIPC方案中，观察到WAnT后120分钟白细胞介素-6浓度显著降低15.5%（p<0.05），以及WAnT后60分钟制瘤素M增加12.2%（p<0.01）。
结果证明了连续10天RIPC程序在调节运动表现和运动后炎症标志物方面的有效性。
