Chandrasekhar Venkata, Rajan Kohulan, Kanakam Sri Ram Sagar, Sharma Nisha, Weißenborn Viktor, Schaub Jonas, Steinbeck Christoph
Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Lessingstr 8, 07743, Jena, Germany.
Nucleic Acids Res. 2025 Jan 6;53(D1):D634-D643. doi: 10.1093/nar/gkae1063.
The COCONUT (COlleCtion of Open Natural prodUcTs) database was launched in 2021 as an aggregation of openly available natural product datasets and has been one of the biggest open natural product databases since. Apart from the chemical structures of natural products, COCONUT contains information about names and synonyms, species and organism parts in which the natural product has been found, geographic information about where the respective sample has been collected and literature references, where available. COCONUT is openly accessible at https://coconut.naturalproducts.net. Users can search textual information and perform structure, substructure, and similarity searches. The data in COCONUT are available for bulk download as SDF, CSV and a database dump. The web application for accessing the data is open-source. Here, we describe COCONUT 2.0, for which the web application has been completely rewritten, and the data have been newly assembled and extensively curated. New features include data submissions by users and community curation facilitated in various ways.
COCONUT（开放天然产物集合）数据库于2021年推出，它聚合了公开可用的天然产物数据集，自此一直是最大的开放天然产物数据库之一。除了天然产物的化学结构外，COCONUT还包含有关名称和同义词、发现天然产物的物种及生物体部位、采集相应样本的地理信息以及文献参考（如有）等信息。可通过https://coconut.naturalproducts.net公开访问COCONUT。用户可以搜索文本信息并执行结构、子结构和相似性搜索。COCONUT中的数据可作为SDF、CSV和数据库转储进行批量下载。用于访问数据的网络应用程序是开源的。在此，我们介绍COCONUT 2.0，其网络应用程序已完全重写，数据也已重新组装并经过广泛整理。新功能包括用户数据提交以及以各种方式促进社区管理。
