González Aroca Joaquín
Faculty of Sciences, Universidad de La Serena, Chile.
Rev Esp Enferm Dig. 2025 Aug;117(8):484-485. doi: 10.17235/reed.2024.10917/2024.
Mendelian randomization (MR) offers a more rigorous framework than traditional observational studies by using genetic variants to assess causal relationships. Three critical assumptions are necessary for MR validity: relevance, independence, and exclusion restriction. These assumptions ensure that the genetic variants accurately reflect the risk factor's impact on the outcome. By elucidating these key points, this article aims to enhance understanding of MR's strengths and limitations in epidemiological research.
孟德尔随机化（MR）通过使用基因变异来评估因果关系，提供了一个比传统观察性研究更严格的框架。MR有效性需要三个关键假设：相关性、独立性和排除限制。这些假设确保基因变异准确反映风险因素对结果的影响。通过阐明这些关键点，本文旨在增进对MR在流行病学研究中的优势和局限性的理解。
