Mir Amatullah, Zhu Angie, Lau Rico, Barr Nicolás, Sheikh Zyva, Acuna Diana, Dayal Anuhya, Hibino Narutoshi
Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Pediatric Cardiac Surgery, Advocate Children's Hospital, 4440 W 95th St., Oak Lawn, IL 60453, USA.
Bioengineering (Basel). 2024 Oct 30;11(11):1096. doi: 10.3390/bioengineering11111096.
Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation.
生物技术的最新进展为体外临床试验（CTiDs）成为生物医学中一种流行的实验方法铺平了道路。CTiDs通过诱导多能干细胞、全基因组测序和芯片器官等技术在转化研究中发挥着重要作用。在本综述中，我们探讨了推动这些CTiD生物技术发展的进展及其在动物试验、疾病建模和空间辐射技术中的应用。此外，本综述剖析了CTiDs的优缺点及其监管考量。最后，我们评估了CTiDs带来的挑战以及它们在未来实验中的作用。
