Brook J D, Chandley A C
Mutat Res. 1986 Apr;164(2):117-25. doi: 10.1016/0165-1161(86)90050-6.
Dyad scores of metaphase II spermatocytes in the mouse have been used as an end point to assess the aneuploidy-inducing potential of three different chemicals; p-fluorophyalanine, phenylalanine and 6-mercaptopurine. The sensitivities of three different spermatogenic stages have been tested; pre-leptotene, zygotene and metaphase I. No effect was found at any treated stage for 6-mercaptopurine and phenylalanine. p-Fluorophenylalanine, when compared to control treatments, did, however, induce non-disjunction when applied at metaphase I. It also caused a delay to spermatogenesis when applied at this stage. The potential of mammalian test systems for the routine screening of chemicals as non-disjunction inducers, is discussed.
小鼠中期II精母细胞的二价体分数已被用作评估三种不同化学物质（对氟苯丙氨酸、苯丙氨酸和6-巯基嘌呤）诱导非整倍体潜力的终点指标。研究测试了三个不同生精阶段（细线前期、偶线期和中期I）的敏感性。对于6-巯基嘌呤和苯丙氨酸，在任何处理阶段均未发现影响。然而，与对照处理相比，对氟苯丙氨酸在中期I应用时会诱导不分离。在此阶段应用时，它还会导致精子发生延迟。文中讨论了哺乳动物测试系统用于常规筛选作为非整倍体诱导剂的化学物质的潜力。
