Clinical Pharmacy Department, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Ras Sudr, 46612, Egypt.
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
AAPS PharmSciTech. 2024 Nov 27;25(8):274. doi: 10.1208/s12249-024-02998-1.
The objective of this study was to assess the use of pMDI alone and pMDI with different spacers in asthmatic patients and to identify any associations between errors in handling the device for the first time and the sessions needed to reach the correct handling method, considering patient demographics and clinical characteristics. A total of 150 Asthmatic patients were crossed over to handle pMDI alone and with add-on inhalable devices (Aerochamber plus, Tips Haler, Able, Dispozable and Aer-8) randomly, without receiving verbal or demonstrative instruction (baseline assessment). The assessment of the inhaler technique was performed using checklists that had been set beforehand. Subsequently, the proper utilization of the inhaler was exhibited, and the patient's inhaler usage was reassessed. The demonstration was repeated until an optimal technique was attained. The number of counselling attempts required to achieve successful management, together with patient demographics and clinical factors, were documented. The mean percentage of total errors at baseline shows that pMDI alone is significantly higher than pMDI attached to add-on devices (53.90 ± 9.71, 32.54 ± 13.93, 24.53 ± 14.93, 21.6 ± 14.48, 25.14 ± 10.99, 27.47 ± 10.28) for pMDI alone, Aerochamber plus, Tips Haler, Able, Dispozable and Aer-8 respectively at p < 0.01. Able and Tips Haler spacers are significantly lower than other spacers with pMDI and pMDI alone in terms of total sessions needed to attain the complete optimal handling technique at p < 0.01. Weak and very weak correlations were observed between the percentage of total errors at baseline and the total sessions with education years, Montreal Cognitive Assessment, and age as well as some demographics and clinical variables. Handling pMDI can be challenging however the introduction of spacers simplifies this procedure. Different spacers cannot be treated as a homogeneous group due to variations in handling techniques and ease of use. the Able spacer requires the fewest handling steps of any spacer and has the highest percentage of patients who can use it without assistance.
本研究旨在评估哮喘患者单独使用 pMDI 和不同附加吸入器(Aerochamber plus、Tips Haler、Able、Dispozable 和 Aer-8)时的使用情况,并确定首次使用装置时的操作错误与达到正确操作方法所需的次数之间的关系,同时考虑患者的人口统计学和临床特征。共有 150 名哮喘患者被随机交叉处理单独使用 pMDI 和附加吸入器(Aerochamber plus、Tips Haler、Able、Dispozable 和 Aer-8),未接受口头或示范指导(基线评估)。吸入器技术的评估使用事先设定的检查表进行。随后,展示正确的吸入器使用方法,并重新评估患者的吸入器使用情况。重复演示,直到达到最佳技术。记录达到成功管理所需的咨询尝试次数,以及患者的人口统计学和临床因素。基线时总错误的平均百分比表明,单独使用 pMDI 显著高于附加附加装置的 pMDI(53.90±9.71、32.54±13.93、24.53±14.93、21.6±14.48、25.14±10.99、27.47±10.28),分别为单独使用 pMDI、Aerochamber plus、Tips Haler、Able、Dispozable 和 Aer-8,p<0.01。与单独使用 pMDI 和其他附加装置相比,Able 和 Tips Haler 间隔器在达到完全最佳操作技术所需的总次数方面明显更低,p<0.01。在基线时总错误百分比与教育年限、蒙特利尔认知评估和年龄以及一些人口统计学和临床变量之间观察到弱和非常弱的相关性。单独使用 pMDI 可能具有挑战性,但引入间隔器可简化此过程。不同的间隔器不能被视为一个同质的群体,因为操作技术和易用性存在差异。Able 间隔器需要的操作步骤最少,无需辅助即可使用的患者比例最高。