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Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3.附录:使用AlphaFold 3对生物分子相互作用进行准确的结构预测。
Nature. 2024 Dec;636(8042):E4. doi: 10.1038/s41586-024-08416-7.
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Accurate structure prediction of biomolecular interactions with AlphaFold 3.利用 AlphaFold 3 进行生物分子相互作用的精确结构预测。
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Review of AlphaFold 3: Transformative Advances in Drug Design and Therapeutics.《AlphaFold 3综述:药物设计与治疗学的变革性进展》
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Heterozygous variants in affect hearing, vision, cardiac, and immune function.[基因名称]中的杂合变异会影响听力、视力、心脏和免疫功能。 (注:原文中“in”后面缺少具体基因名称,需补充完整才能准确翻译)
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Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy.用于间皮素低表达实体瘤治疗的间皮素导向蛋白-药物偶联物
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The translation initiation factor DHX29 appears to pull on mRNA in a direction opposite to scanning.翻译起始因子DHX29似乎以与扫描相反的方向拉动信使核糖核酸(mRNA)。
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FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance.真菌抗菌药物耐药性:一个用于研究与抗菌药物耐药性相关真菌突变的综合数据库。
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Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue.通过关键残基调节RING E3泛素连接酶的泛素转移
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The MEC-2E isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans.具有大的C末端的MEC-2E同种型完全挽救了秀丽隐杆线虫的触觉感觉缺陷。
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Leveraging AlphaFold2 structural space exploration for generating drug target structures in structure-based virtual screening.利用AlphaFold2结构空间探索在基于结构的虚拟筛选中生成药物靶点结构。
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Structures of TOM complexes with bound preproteins.结合前体蛋白的TOM复合体结构。
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Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3.

作者信息

Abramson Josh, Adler Jonas, Dunger Jack, Evans Richard, Green Tim, Pritzel Alexander, Ronneberger Olaf, Willmore Lindsay, Ballard Andrew J, Bambrick Joshua, Bodenstein Sebastian W, Evans David A, Hung Chia-Chun, O'Neill Michael, Reiman David, Tunyasuvunakool Kathryn, Wu Zachary, Žemgulytė Akvilė, Arvaniti Eirini, Beattie Charles, Bertolli Ottavia, Bridgland Alex, Cherepanov Alexey, Congreve Miles, Cowen-Rivers Alexander I, Cowie Andrew, Figurnov Michael, Fuchs Fabian B, Gladman Hannah, Jain Rishub, Khan Yousuf A, Low Caroline M R, Perlin Kuba, Potapenko Anna, Savy Pascal, Singh Sukhdeep, Stecula Adrian, Thillaisundaram Ashok, Tong Catherine, Yakneen Sergei, Zhong Ellen D, Zielinski Michal, Žídek Augustin, Bapst Victor, Kohli Pushmeet, Jaderberg Max, Hassabis Demis, Jumper John M

机构信息

Core Contributor, Google DeepMind, London, UK.

Core Contributor, Isomorphic Labs, London, UK.

出版信息

Nature. 2024 Dec;636(8042):E4. doi: 10.1038/s41586-024-08416-7.

DOI:10.1038/s41586-024-08416-7
PMID:39604737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11634763/
Abstract
摘要