Rostampour Kimia, Moghtaderi Fatemeh, Najafi AmirHossein, Seyedjafari Behnaz, Salehi-Abargouei Amin
Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Front Nutr. 2024 Nov 13;11:1475962. doi: 10.3389/fnut.2024.1475962. eCollection 2024.
The effect of non-nutritive sweeteners (NNSs) on long-term satiety is not well understood. This systematic review and meta-analysis were performed to investigate the effect of NNSs on long-term total energy and macronutrients intake.
Online databases including Scopus, PubMed, ISI Web of Science, and Google Scholar were searched up to September 2024 to find relevant randomized control trials (RCTs). A random effects model was used for estimating the overall effects.
The results showed a reducing effect of NNSs consumption vs. sugar on total energy intake [total energy intake change = -175.26 kcal/day, 95% confidence interval (CI): -296.47 to -54.06, I = 61.19%] and carbohydrate intake [Hedges' g = -0.35, 95% CI: -0.63 to -0.06, I = 58.99%]. While, NNSs intake vs. water was not associated with significant change in total energy intake [total energy intake change = 29.94 kcal/day, 95% CI: -70.37 to 130.24, I = 34.98%] and carbohydrate intake [Hedges' g = 0.28, 95% CI: -0.02 to 0.58, I = 65.26%]. The Consumption of NNSs compared to the either sugar or water did not have a significant effect on fat intake [Hedges' g = 0.08, 95% CI: -0.10 to 0.26, I = 8.73%/ fat intake change = 0.20 g/day, 95% CI: -3.48 to 3.88, I = 0%] and Protein intake [Hedges' g = 0.16, 95% CI: -0.11 to 0.42, I = 50.83%/Hedges' g = 0.00, 95% CI: -0.15 to 0.16, I = 0%].
In summary, our findings suggest that NNSs consumption may be effective in reducing total energy and carbohydrate intake compared to sugar.
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=432816, CRD42023432816.
非营养性甜味剂（NNSs）对长期饱腹感的影响尚不清楚。本系统评价和荟萃分析旨在研究NNSs对长期总能量和宏量营养素摄入的影响。
检索了包括Scopus、PubMed、ISI Web of Science和谷歌学术在内的在线数据库，截至2024年9月，以查找相关的随机对照试验（RCTs）。采用随机效应模型估计总体效应。
结果显示，与糖相比，食用NNSs对总能量摄入有降低作用[总能量摄入变化=-175.26千卡/天，95%置信区间（CI）：-296.47至-54.06，I=61.19%]和碳水化合物摄入[Hedges'g=-0.35，95%CI：-0.63至-0.06，I=58.99%]。而与水相比，摄入NNSs与总能量摄入[总能量摄入变化=29.94千卡/天，95%CI：-70.37至130.24，I=34.98%]和碳水化合物摄入[Hedges'g=0.28，95%CI：-0.02至0.58，I=65.26%]的显著变化无关。与糖或水相比，食用NNSs对脂肪摄入[Hedges'g=0.08，95%CI：-0.10至0.26，I=8.73%/脂肪摄入变化=0.20克/天，95%CI：-3.48至3.88，I=0%]和蛋白质摄入[Hedges'g=0.16，95%CI：-0.11至0.42，I=50.83%/Hedges'g=0.00，95%CI：-0.15至0.16，I=0%]没有显著影响。
总之，我们的研究结果表明，与糖相比，食用NNSs可能有助于降低总能量和碳水化合物的摄入。
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=432816，CRD42023432816。
