Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA.
Department of pathology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA.
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241298147. doi: 10.1177/23247096241298147.
The abdomen, particularly the ileocecal region, is the most commonly affected disease site in sporadic Burkitt lymphoma (BL). Involvement of the stomach is very rare. Primary gastric atypical Burkitt lymphoma has not been described in the literature, to the best of our knowledge. In this case report, we discuss a patient with atypical Burkitt lymphoma involving the stomach. The immunohistochemical stains showed positive results for CD20, PAX5, BCL6, CD10, and high ki-67. The fluorescence in situ hybridization (FISH) test revealed a positive result for c-MYC gene rearrangement, but there was no evidence of the typical translocation associated with Burkitt lymphoma involving the IgH, kappa, or lambda genes.
腹部，特别是回盲部，是散发性伯基特淋巴瘤（BL）最常累及的部位。胃受累非常罕见。据我们所知，原发性胃非典型伯基特淋巴瘤尚未在文献中描述。在本病例报告中，我们讨论了一例累及胃的非典型伯基特淋巴瘤患者。免疫组化染色显示 CD20、PAX5、BCL6、CD10 阳性，Ki-67 高表达。荧光原位杂交（FISH）检测显示 c-MYC 基因重排阳性，但没有与涉及 IgH、kappa 或 lambda 基因的伯基特淋巴瘤相关的典型易位的证据。
