Self-supervised learning on dual-sequence magnetic resonance imaging for automatic segmentation of nasopharyngeal carcinoma.

Automating the segmentation of nasopharyngeal carcinoma (NPC) is crucial for therapeutic procedures but presents challenges given the hurdles in amassing extensively annotated datasets. Although previous studies have applied self-supervised learning to capitalize on unlabeled data to improve segmentation performance, these methods often overlooked the benefits of dual-sequence magnetic resonance imaging (MRI). In the present study, we incorporated self-supervised learning with a saliency transformation module using unlabeled dual-sequence MRI for accurate NPC segmentation. 44 labeled and 72 unlabeled patients were collected to develop and evaluate our network. Impressively, our network achieved a mean Dice similarity coefficient (DSC) of 0.77, which is consistent with a previous study that relied on a training set of 4,100 annotated cases. The results further revealed that our approach required minimal adjustments, primarily < 20% tweak in the DSC, to meet clinical standards. By enhancing the automatic segmentation of NPC, our method alleviates the annotation burden on oncologists, curbs subjectivity, and ensures reliable NPC delineation.