LeFevre M E, Joel D D
Proc Soc Exp Biol Med. 1986 May;182(1):112-9. doi: 10.3181/00379727-182-42318.
Single doses of 7Be-labeled carbon particles prepared by proton bombardment of carbon black were administered by gavage to weanling (4 weeks) and aged (18 months) mice. Body distribution of 7Be radioactivity was determined 4 hr and 1, 2, 5, and 14 days later. The results were compared with those obtained after administration of a solution of 7BeCl2. 7Be radioactivity in nonintestinal tissues was 17-58 times greater in mice gavaged with the soluble salt than in those gavaged with the particles, indicating that particle-bound 7Be was well confined to the gastrointestinal tract. Upper limits of the amount of labeled carbon remaining in intestinal Peyer's patches were as follows: 1 day: weanling, 1.8 X 10(-3)%, old, 5.5 X 10(-3)%; 15 days: weanling, 3.3 X 10(-5)%, old, 8.4 X 10(-5)%. The particles are potentially useful as models for diesel emissions or other particulate pollutants.
通过用质子轰击炭黑制备的单剂量7Be标记碳颗粒经口灌胃给予断奶（4周龄）和老龄（18月龄）小鼠。在给药后4小时以及1、2、5和14天测定7Be放射性的全身分布。将结果与给予7BeCl2溶液后获得的结果进行比较。用可溶性盐灌胃的小鼠非肠道组织中的7Be放射性比用颗粒灌胃的小鼠高17 - 58倍，这表明与颗粒结合的7Be很好地局限于胃肠道。肠道派伊尔结中残留的标记碳量上限如下：1天：断奶小鼠，1.8×10(-3)%，老龄小鼠，5.5×10(-3)%；15天：断奶小鼠，3.3×10(-5)%，老龄小鼠，8.4×10(-5)%。这些颗粒有可能作为柴油排放物或其他颗粒污染物的模型。
