Cikrt M, Bencko V
Arch Toxicol. 1975 Sep 5;34(1):53-60. doi: 10.1007/BF00353339.
Wistar female rats were given two i.v. doses of 7BeCl2 (dose A = 0.025 mg Be2+/kg b.w.; dose B = 0.25 mg Be2+/kg b.w.). The rats were decapitated at 5, 24, and 48 hrs after administration. The kinetics of 7Be bile excretion during the 5 hrs after administration, as well as 7Be retention in selected organs and the urine and stool excretion of beryllium were investigated. Significant differences between the effect of both doses were found particularly in the shape of biliary excretion curves of 7Be. Unproportionally higher 7Be blood levels after a higher dose persisted for a longer period of time. The decrease of 7Be in blood after a higher dose between the 5th and 24th hr after the administration was accompanied by an increased content of 7Be in the liver and spleen as well as by an increased urine excretion. The results obtained tend to prove that the reticuloendothelial system mainly participated in beryllium retention. Urine represents the main excretion route of beryllium after a parenteral administration.
给雌性Wistar大鼠静脉注射两剂7BeCl2（剂量A = 0.025毫克铍离子/千克体重；剂量B = 0.25毫克铍离子/千克体重）。给药后5小时、24小时和48小时将大鼠断头。研究了给药后5小时内7Be胆汁排泄的动力学，以及7Be在选定器官中的潴留情况和铍的尿液及粪便排泄情况。发现两种剂量的作用之间存在显著差异，特别是在7Be胆汁排泄曲线的形状方面。较高剂量后不成比例的较高7Be血药浓度持续时间更长。给药后较高剂量在第5小时至第24小时之间血中7Be的减少伴随着肝脏和脾脏中7Be含量的增加以及尿液排泄的增加。所获得的结果倾向于证明网状内皮系统主要参与铍的潴留。静脉给药后，尿液是铍的主要排泄途径。
