Dackis C A, Gold M S, Pottash A L, Sweeney D R
Psychiatry Res. 1986 Feb;17(2):105-9. doi: 10.1016/0165-1781(86)90065-x.
The persistence of untreated depression was evaluated in 49 severely depressed alcoholics. After 2 weeks of sobriety, 80% of patients with initial major depression by Research Diagnostic Criteria were no longer depressed. These patients improved without antidepressant medications, suggesting the need for a 2-week period of sobriety before psychopharmacotherapy for depression is instituted. Many severe depressions in actively drinking or recently sober alcoholics may represent alcohol-induced organic affective syndromes which, unlike major depressive illness, remit spontaneously with sobriety.
对49名重度抑郁的酗酒者的未治疗抑郁症持续情况进行了评估。在戒酒2周后，根据研究诊断标准最初患有重度抑郁症的患者中，80%不再抑郁。这些患者在未使用抗抑郁药物的情况下病情好转，这表明在开始针对抑郁症的心理药物治疗之前，需要有2周的戒酒期。许多正在饮酒或近期刚戒酒的酗酒者的重度抑郁症可能代表酒精所致的器质性情感综合征，与重度抑郁障碍不同，这种综合征会随着戒酒而自发缓解。
