Qiu Pengjia, Wang Lei, Wang Jing, Wang Xingdong, Xu Jianchao, An Xiaokai, Han Fengwang, Dong Zhao, Zhang Jiangtao, Shi Peiwen, Niu Qiang
Department of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, China.
Department of Orthopedics, Sichuan Gemflower Hospital, North Sichuan Medical College, Sichuan, China.
Front Cell Dev Biol. 2024 Nov 14;12:1499766. doi: 10.3389/fcell.2024.1499766. eCollection 2024.
With the rapid progress of industrialization, the incidence of peripheral nerve injuries caused by trauma has been continuously increasing. These injuries result in a significant number of disabilities and irreversible functional impairments, not only severely impacting the health and quality of life of patients but also placing a heavy economic burden on families and society. Effectively promoting peripheral nerve regeneration has thus become a key focus and challenge in current research. In recent years, hybrid biohydrogels with adhesive properties have gained widespread attention due to their excellent biocompatibility, mechanical stability, conductivity, and biodegradability. These materials can provide an optimal microenvironment to promote neuron adhesion and axonal extension while offering outstanding mechanical strength to meet the fixation requirements in clinical surgeries. This paper systematically reviews the application of adhesive hybrid biohydrogels in peripheral nerve injury repair, highlighting the latest research progress in promoting nerve regeneration and improving functional recovery, and discusses the challenges and future prospects for their clinical application.
随着工业化的快速发展，创伤引起的周围神经损伤发病率不断上升。这些损伤导致大量残疾和不可逆转的功能障碍，不仅严重影响患者的健康和生活质量，还给家庭和社会带来沉重的经济负担。因此，有效促进周围神经再生已成为当前研究的关键重点和挑战。近年来，具有粘附特性的混合生物水凝胶因其优异的生物相容性、机械稳定性、导电性和生物降解性而受到广泛关注。这些材料可以提供一个最佳的微环境，以促进神经元粘附和轴突延伸，同时提供出色的机械强度，以满足临床手术中的固定要求。本文系统综述了粘附性混合生物水凝胶在周围神经损伤修复中的应用，突出了在促进神经再生和改善功能恢复方面的最新研究进展，并讨论了其临床应用面临的挑战和未来前景。
