Tricottet V, Bruneval P, Vire O, Camilleri J P, Bloch F, Bonte N, Roge J
Ultrastruct Pathol. 1986;10(2):113-22. doi: 10.3109/01913128609014587.
A prospective light and electron microscopic study of repeated endoscopic gastric biopsy specimens obtained from 10 patients presenting at the first examination for long-standing erosive gastritis was performed. In nearly all specimens from 7 patients, spiral bacteria were found in close contact to the surface epithelial cells and associated with active inflammatory changes. These organisms appeared similar to those recently described as gastric "campylobacter-Like organisms" (GCLO). It is possible that they are related to unusual anaerobic spirochetes. In the specimens obtained after antibiotic-therapy the bacteria were few in number and damaged. At the ultrastructural level, the presence of cell necrosis and autolytic intracytoplasmic vacuoles combined with damaged bacteria may suggest a relationship between GCLO surface colonization and erosive epithelial abnormality. Such colonization does not occur in normal mucosa.
对10例因长期糜烂性胃炎首次就诊患者的重复内镜胃活检标本进行了前瞻性光镜和电镜研究。在7例患者的几乎所有标本中，发现螺旋菌与表面上皮细胞紧密接触，并伴有活动性炎症改变。这些微生物与最近描述的胃“弯曲菌样微生物”（GCLO）相似。它们可能与异常厌氧螺旋体有关。抗生素治疗后获得的标本中细菌数量少且有损伤。在超微结构水平上，细胞坏死和自溶性胞浆空泡的存在以及细菌的损伤可能提示GCLO表面定植与糜烂性上皮异常之间的关系。这种定植在正常黏膜中不发生。
