Zhang Mengli, Yuan Yucheng, Huang Yuqing, Ge Yiping, Wu Qiuju
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangwangmiao Street 12, Xuanwu District, Nanjing, 210042, Jiangsu Province, People's Republic of China.
Aesthetic Plast Surg. 2025 Mar;49(5):1554-1558. doi: 10.1007/s00266-024-04534-9. Epub 2024 Dec 2.
The role of fractional picosecond-domain lasers in scar remodeling is being increasingly recognized. In this study, we aimed to evaluate the efficacy of a fractional 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) picosecond laser for treating early-stage traumatic and surgical scars in an Asian population.
Thirty-seven patients with 49 early-stage traumatic and surgical scar lesions were enrolled. Participants underwent three treatment sessions with a fractional 1064-nm Nd:YAG picosecond laser at 4-8-week intervals. Two non-involved dermatologists evaluated the treatment response using the Vancouver Scar Scale (VSS) and Global Aesthetic Improvement Scale (GAIS).
After treatment, the early-stage traumatic and surgical scars significantly improved. The treatment effects differed markedly according to the number of treatment sessions (F=219.71, P<0.001). The VSS scores were 5.56 ± 2.17 and 3.85 ± 2.02 in the postoperative period after one (P<0.001) and three (P<0.001) sessions, respectively, compared with the baseline VSS score (6.94 ± 1.85). After three treatment sessions, 69.39% of the scars improved based on the GAIS scores.
This study was limited by the small number of participants involved and the lack of a control group.
The fractionated 1064-nm Nd:YAG picosecond laser effectively treated early-stage traumatic and surgical scars in an Asian population.
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分数皮秒域激光在瘢痕重塑中的作用日益受到认可。在本研究中，我们旨在评估1064纳米掺钕钇铝石榴石（Nd:YAG）分数皮秒激光治疗亚洲人群早期创伤性和手术瘢痕的疗效。
纳入37例患有49处早期创伤性和手术瘢痕病变的患者。参与者接受了3次1064纳米Nd:YAG分数皮秒激光治疗，每次间隔4至8周。两名未参与的皮肤科医生使用温哥华瘢痕量表（VSS）和整体美学改善量表（GAIS）评估治疗反应。
治疗后，早期创伤性和手术瘢痕明显改善。治疗效果根据治疗次数有显著差异（F=219.71，P<0.001）。与基线VSS评分（6.94±1.85）相比，一次治疗后（P<0.001）和三次治疗后（P<0.001）的术后VSS评分分别为5.56±2.17和3.85±2.02。三次治疗后，根据GAIS评分，69.39%的瘢痕得到改善。
本研究受参与人数少和缺乏对照组的限制。
1064纳米Nd:YAG分数皮秒激光有效治疗了亚洲人群的早期创伤性和手术瘢痕。
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