Department of Cosmetic Laser Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, 210042, P.R. China.
Lasers Surg Med. 2020 Feb;52(2):176-181. doi: 10.1002/lsm.23177. Epub 2019 Nov 10.
Recently, picosecond laser treatment has been used as an effective treatment for acne scars. To evaluate the efficacy and safety of a picosecond alexandrite laser with a diffractive lens array in the treatment of acne scars in Chinese patients.
STUDY DESIGN/MATERIALS AND METHODS: Patients with facial acne scars were treated with a picosecond alexandrite laser in three sessions at 4- to 6-week intervals and followed up for 2 months. Primary outcomes were measured by physicians' blinded evaluation of the acne scar using the ECCA (échelle d'éva physicians'luation clinique des cicatrices d'acné) grading scale. The secondary outcomes included the investigator global assessment (IGA) on the improvement of post-inflammatory erythema (PIE), patients' assessment of improvement on a 4-point scale and of satisfaction on a 5-point scale. Pain scores and adverse effects were also evaluated.
Twenty patients with Fitzpatrick skin types III and IV were enrolled in the study and completed all treatment and follow-up visits. The mean ECCA scores fell from 197.75 ± 35.26 to 142.00 ± 35.92 (a 28% improvement), and the change was significant (P = 0.000). The mean IGA score of PIE improvement was 3.03 ± 0.75 (0 = no improvement and 4 = 76-100% improvement). On the basis of the patients' self-assessment, the average improvement scores were 2.30 ± 0.98 (0 indicating 0-25% improvement and 3 indicating >75% improvement). In total, 50% and 30% of the patients were "satisfied" and "very satisfied," respectively, with the treatment. The mean pain score was 3.20 ± 0.50 (0 = no pain, 10 = maximum pain) with topical anesthesia. The adverse effects included transient and mild erythema, edema, and scabbing.
Treatment with a picosecond alexandrite laser with a diffractive lens array is effective and safe for acne scars in Chinese patients. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.
最近，皮秒激光已被用作治疗痤疮瘢痕的有效方法。本研究旨在评估使用带有衍射透镜阵列的皮秒翠绿宝石激光治疗中国患者痤疮瘢痕的疗效和安全性。
研究设计/材料和方法：将面部痤疮瘢痕患者在 4-6 周的间隔内接受三次皮秒翠绿宝石激光治疗，并随访 2 个月。主要疗效指标为医生使用痤疮瘢痕 ECCA（痤疮临床评估量表）分级标准对痤疮瘢痕进行盲法评估。次要疗效指标包括研究者对炎症后红斑（PIE）改善的总体评估（IGA）、患者对 4 分制改善程度的评估和对 5 分制满意度的评估。还评估了疼痛评分和不良反应。
20 例 Fitzpatrick 皮肤类型为 III 或 IV 的患者入组并完成了所有治疗和随访。ECCA 评分从 197.75±35.26 降至 142.00±35.92（改善 28%），差异有统计学意义（P=0.000）。PIE 改善的 IGA 平均评分为 3.03±0.75（0 表示无改善，4 表示 76%-100%改善）。基于患者的自我评估，平均改善评分为 2.30±0.98（0 表示 0%-25%改善，3 表示 >75%改善）。共有 50%和 30%的患者对治疗“满意”和“非常满意”。在局部麻醉下，平均疼痛评分为 3.20±0.50（0 表示无痛，10 表示极度疼痛）。不良反应包括短暂性轻度红斑、水肿和结痂。
使用带有衍射透镜阵列的皮秒翠绿宝石激光治疗中国患者的痤疮瘢痕是有效且安全的。
