Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al Azhar Assiut University, Assiut Governorate, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Cairo University, Giza Governorate, Egypt.
Dermatol Ther. 2019 Sep;32(5):e13031. doi: 10.1111/dth.13031. Epub 2019 Aug 5.
The management of posttraumatic scars is a great challenge. Autologous platelet-rich plasma (APRP) and fractional carbon dioxide (CO2) laser can be applied as innovative treatments for posttraumatic scars. The aim of this study was to evaluate the efficacy, safety and complications of fractional CO2 laser exposure plus APRP injection in treating traumatic scars versus CO2 laser applied as a monotherapy. Twenty participants were treated 3 times at a 4-week interval with a follow-up visit. The scars were divided into an upper and lower half-treated with fractional CO2 laser exposure plus APRP injection and CO2 laser alone, respectively. The scar was evaluated using the Vancouver scar scale (VSS), along with patient satisfaction. Twenty patients completed the 3 month treatment course. The mean VSS score improved significantly from 7.0 ± 3.97 to 3.25 ± 1.55 and 6.75 ± 1.77 to 3.85 ± 1.59 with fractional CO2 laser exposure plus APRP injection and CO2 laser exposure, respectively (p < .001). However, CO2 laser plus APRP was significantly superior to CO2 laser alone (p = .001), with fewer adverse effects. Our study shows that combined treatment with CO2 laser exposure plus APRP injection is safer and more effective for posttraumatic scar management than CO2 laser exposure alone.
外伤性瘢痕的管理是一个巨大的挑战。自体富血小板血浆（APRP）和分数二氧化碳（CO2）激光可作为治疗外伤性瘢痕的创新疗法。本研究旨在评估分数 CO2 激光暴露联合 APRP 注射与 CO2 激光单独治疗外伤性瘢痕的疗效、安全性和并发症。20 名参与者在 4 周的间隔内接受了 3 次治疗，并进行了随访。将瘢痕分为上下两半，分别用分数 CO2 激光暴露联合 APRP 注射和 CO2 激光单独治疗。使用温哥华瘢痕量表（VSS）以及患者满意度评估瘢痕。20 名患者完成了 3 个月的治疗过程。VSS 评分从 7.0±3.97 显著改善至 3.25±1.55 和 6.75±1.77 至 3.85±1.59，分别采用分数 CO2 激光暴露联合 APRP 注射和 CO2 激光暴露（p<.001）。然而，CO2 激光联合 APRP 明显优于 CO2 激光单独治疗（p=0.001），且不良反应更少。我们的研究表明，与 CO2 激光单独治疗相比，CO2 激光暴露联合 APRP 注射治疗外伤性瘢痕更安全、更有效。
