Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Anesthesiology, The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530000, China.
Colloids Surf B Biointerfaces. 2023 Jul;227:113347. doi: 10.1016/j.colsurfb.2023.113347. Epub 2023 May 12.
Radiotherapy (RT) efficacy can be promoted with the help of nanoenzyme that can "re-programing" the tumour's micro-environment by changing the expression level of special bio-molecules. However, problems such as low reaction efficiency, limited endogenous HO, and/or unsatisfactory results of a single catalysis mode in treatment limit the application in the RT field. Herein, a novel Au nanoparticles (AuNPs) decorated iron SAE (FeSAE@Au) was formulated for self-cascade catalytic RT. In this dual-nanozyme system, embedded AuNPs can sever as GOx and endow FeSAE@Au with self-HO supplying ability, which can elevate the HO level in tumors by catalyzing cellular glucose in situ, further improving the catalytic performance of FeSAE with peroxidase-like activity. The self-cascade catalytic reaction can significantly increase cellular hydroxyl radicals (•OH) level, further promoting RT's effect. Furthermore, in vivo findings demonstrated that FeSAE can effectively limit tumor growth while causing low damage in important organs. According to our understanding, FeSAE@Au is the first description of a hybrid SAE-based nanomaterial employed in cascade catalytic RT. The research yields new and interesting insights for developing various SAE systems for anticancer therapy.
纳米酶可以通过改变特定生物分子的表达水平来“重新编程”肿瘤微环境，从而提高放射治疗（RT）的疗效。然而，在治疗中，低反应效率、有限的内源性 HO 和/或单一催化模式的结果不理想等问题限制了其在 RT 领域的应用。在此，我们构建了一种新型的金纳米颗粒（AuNPs）修饰的铁卟啉纳米酶（FeSAE@Au）用于自级联催化 RT。在这个双纳米酶系统中，嵌入的 AuNPs 可以作为葡萄糖氧化酶（GOx），赋予 FeSAE@Au 自身提供 HO 的能力，通过原位催化细胞内的葡萄糖，进一步提高具有过氧化物酶样活性的 FeSAE 的催化性能。自级联催化反应可以显著提高细胞内羟基自由基（•OH）的水平，进一步增强 RT 的效果。此外，体内研究结果表明，FeSAE 可以有效地抑制肿瘤生长，同时对重要器官的损伤较低。据我们所知，FeSAE@Au 是首例用于级联催化 RT 的基于杂化 SAE 的纳米材料的描述。该研究为开发用于癌症治疗的各种 SAE 系统提供了新的有趣的见解。
