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用于体外诊断至即时检测的纳米生物传感器技术进展。

Advancements in nanobiosensor technologies for in-vitro diagnostics to point of care testing.

作者信息

Kim Chuntae, Kang Moon Sung, Raja Iruthayapandi Selestin, Joung Yoon Ki, Han Dong-Wook

机构信息

Institute of Nano-Bio Convergence, Pusan National University (PNU), 46241, South Korea.

Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, 02792, South Korea.

出版信息

Heliyon. 2024 Nov 9;10(22):e40306. doi: 10.1016/j.heliyon.2024.e40306. eCollection 2024 Nov 30.

Abstract

Recently, the importance of rapid testing nanosensor technologies for in-vitro diagnostics (IVD) and point-of-care testing (POCT) is being increasingly recognized. Owing to their high sensitivity and rapidity, nanosensor-based diagnostic devices are evolving into self-diagnostic tools that enable real-time in-situ analyses. These advances have become the focus of the public health control system, not only to prevent the spread of infectious diseases but also to enable the early detection of critical diseases through continuous health monitoring technologies. Current research on rapid diagnostic nanosensor technologies has focused on improving accuracy, sensitivity, rapid test systems, cost-effectiveness, and accessibility. In this review, we discuss the development of self-testing IVD technologies based on rapid diagnostic nanosensor platforms. The convergence of nanosensors and advanced materials can provide faster, more accurate, and more accessible IVD-based POCT solutions, representing an important advancement in healthcare. Here, we present nanosensor technologies for diagnosing biomarkers in in-vitro samples and improving diagnostic efficiency. Nanosensor-based self-diagnostic devices have the potential to be extended to personalized healthcare platforms, enabling the continuous monitoring of infectious diseases, cancer, and other serious issues. This review highlights the importance of research in this field to improve diagnostic efficiency.

摘要

最近,用于体外诊断(IVD)和即时检测(POCT)的快速检测纳米传感器技术的重要性日益得到认可。由于其高灵敏度和快速性,基于纳米传感器的诊断设备正在演变成能够进行实时原位分析的自我诊断工具。这些进展已成为公共卫生控制系统的焦点,不仅用于预防传染病的传播,还用于通过持续健康监测技术实现对重大疾病的早期检测。目前关于快速诊断纳米传感器技术的研究集中在提高准确性、灵敏度、快速检测系统、成本效益和可及性方面。在这篇综述中,我们讨论了基于快速诊断纳米传感器平台的自我检测IVD技术的发展。纳米传感器与先进材料的融合可以提供更快、更准确、更易获得的基于IVD的POCT解决方案,这代表了医疗保健领域的一项重要进展。在此,我们介绍用于诊断体外样本中生物标志物和提高诊断效率的纳米传感器技术。基于纳米传感器的自我诊断设备有潜力扩展到个性化医疗平台,实现对传染病、癌症和其他严重问题的持续监测。这篇综述强调了该领域研究对于提高诊断效率的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4680/11609235/dfdda093f627/gr1.jpg

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