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小儿胃食管反流病的胃底折叠术:适应证、技术及疗效

Fundoplication for Pediatric Gastroesophageal Reflux Disease: Indications, Techniques, and Outcomes.

作者信息

Al-Refaie Maimona A, Alsurmi Mohammed M, Obadiel Yasser A, Jowah Haitham M, Alsharafy Khaled M

机构信息

Department of Pediatric Surgery, Al-Thawra Modern General Hospital, Sana'a, YEM.

Department of Pediatric and Neonatal Surgery, Al-Thawra Modern General Hospital, Sana'a, YEM.

出版信息

Cureus. 2024 Nov 3;16(11):e72930. doi: 10.7759/cureus.72930. eCollection 2024 Nov.

Abstract

Background This study aimed to evaluate the indications, techniques, and outcomes of fundoplication in pediatric patients with gastroesophageal reflux disease (GERD) at a tertiary hospital in Yemen. Methods A prospective cohort study was conducted at Al-Thawra Modern General Hospital, Sana'a, Yemen, between January 2015 and January 2022. The study included 45 pediatric patients under 18 years of age who underwent fundoplication for GERD. Data on demographic and clinical characteristics, surgical type, postoperative complications, and follow-up outcomes were collected and analyzed. Results The median age of the 45 pediatric patients was two years (range: two months to 10 years), with 25 males (56%) and 20 females (44%). The primary indications for fundoplication included GERD with hiatal hernia in 20 patients (44.4%), persistent symptoms despite medical management in 9 patients (20%), recurrent chest infections associated with neurological disorders in 7 patients (15.6%), esophageal stricture in 8 patients (17.8%), and both hiatal hernia and esophageal stricture in 1 patient (2.2%). Nissen fundoplication was performed in 36 patients (80%), and Thal fundoplication was performed in 9 patients (20%). Complete symptom resolution was achieved in 31 patients (68.89%). Dysphagia due to postoperative esophageal stricture was the most common complication, affecting 13 patients (29%). A structured dilatation protocol resulted in improvement after one session in four patients (30.8%), regular sessions in six patients (46.2%), and irregular sessions in three patients (23.1%). The mortality rate was two patients (5.56%), both of whom had cerebral palsy and died due to recurrent chest infections unrelated to GERD recurrence or esophageal stricture. Conclusions Fundoplication is a safe and effective surgical treatment for pediatric GERD, with a high success rate and manageable complications. A structured postoperative dilatation protocol is essential for managing esophageal strictures and improving outcomes. Early diagnosis and intervention, alongside adherence to postoperative protocols, are crucial for optimal results. Further research with larger sample sizes and long-term follow-up is recommended to confirm these findings and improve clinical practice.

摘要

背景 本研究旨在评估也门一家三级医院中,小儿胃食管反流病(GERD)患者行胃底折叠术的适应证、技术及疗效。方法 2015年1月至2022年1月在也门萨那的宰赫拉现代综合医院进行了一项前瞻性队列研究。该研究纳入了45例18岁以下因GERD接受胃底折叠术的小儿患者。收集并分析了人口统计学和临床特征、手术类型、术后并发症及随访结果的数据。结果 45例小儿患者的中位年龄为2岁(范围:2个月至10岁),其中男性25例(56%),女性20例(44%)。胃底折叠术的主要适应证包括:20例(44.4%)伴有食管裂孔疝的GERD、9例(20%)经药物治疗后仍有持续症状、7例(15.6%)与神经疾病相关的反复胸部感染、8例(17.8%)食管狭窄,以及1例(2.2%)同时患有食管裂孔疝和食管狭窄。36例(80%)患者行nissen胃底折叠术,9例(20%)患者行thal胃底折叠术。31例(68.89%)患者症状完全缓解。术后食管狭窄导致的吞咽困难是最常见的并发症,影响了13例患者(29%)。结构化扩张方案使4例患者(30.8%)在一次治疗后病情改善,6例患者(46.2%)在规律治疗后病情改善,3例患者(23.1%)在不规律治疗后病情改善。死亡率为2例患者(5.56%),这2例均患有脑瘫,死于与GERD复发或食管狭窄无关的反复胸部感染。结论 胃底折叠术是治疗小儿GERD的一种安全有效的手术方法,成功率高且并发症可控。结构化的术后扩张方案对于处理食管狭窄和改善疗效至关重要。早期诊断和干预以及遵守术后方案对于取得最佳效果至关重要。建议进行更大样本量和长期随访的进一步研究以证实这些发现并改善临床实践。

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J Pediatr Surg. 2021 Sep;56(9):1495-1499. doi: 10.1016/j.jpedsurg.2021.02.045. Epub 2021 Feb 24.
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Gastroesophageal reflux disease (GERD) in children.儿童胃食管反流病
Paediatr Int Child Health. 2019 Feb;39(1):7-12. doi: 10.1080/20469047.2018.1489649. Epub 2018 Aug 6.
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Gastroesophageal reflux.胃食管反流
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