Rai Kamal, Brown Patrick E
Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada.
Centre for Global Health Research, St. Michael's Hospital, Toronto, ON, Canada.
J Appl Stat. 2024 Jun 18;51(16):3366-3385. doi: 10.1080/02664763.2024.2351467. eCollection 2024.
We propose a model for multiple waves of an epidemic that decomposes the health outcome of interest into the sum of scaled skew normal curves. When applied to daily COVID-19 mortality in six regions (Japan, Italy, Belgium, Ontario, Texas, and Peru), this model provides three notable results. First, when fit to data from early 2020 to May 31, 2022, the estimated skew normal curves substantially overlap with the dates of COVID-19 waves in Ontario and Belgium, as determined by their respective health authorities. Second, the asymmetry of the skew normal curves changes over time - they progress from increasing more quickly to decreasing more quickly, indicating changes in the relative speed that daily COVID-19 mortality rises and falls over time. Third, most regions have day-of-the-week effects, which suggests that day-of-the-week effects should be included when modeling daily COVID-19 mortality. We conclude by discussing limitations and possible extensions of this model and its results, including commenting on its applicability to potential future COVID-19 waves.
我们提出了一种针对疫情多波次的模型,该模型将感兴趣的健康结果分解为缩放后的偏态正态曲线之和。当将此模型应用于六个地区(日本、意大利、比利时、安大略省、德克萨斯州和秘鲁)的每日新冠死亡率时,得出了三个显著结果。首先,当拟合2020年初至2022年5月31日的数据时,估计的偏态正态曲线与安大略省和比利时各自卫生当局确定的新冠疫情波次日期基本重叠。其次,偏态正态曲线的不对称性随时间变化——它们从上升更快转变为下降更快,这表明每日新冠死亡率随时间上升和下降的相对速度发生了变化。第三,大多数地区存在一周中日期的效应,这表明在对每日新冠死亡率进行建模时应纳入一周中日期的效应。我们通过讨论该模型及其结果的局限性和可能的扩展来结束本文,包括评论其对未来可能的新冠疫情波次的适用性。